Originally published on “Clear Evidence of Cancer” Concludes US National Toxicology”
Scientific panel advises there is evidence for an association between both heart and brain cancers and cell phone radiation in large-scale animal study.
Expanded Press Release (with radio/TV/print news at bottom of page)
(Triangle Park, NC) March 28, 2018
Scientific panel advises there is evidence for an association between both heart and brain cancers and cell phone radiation in large-scale animal study.
(Triangle Park, NC) Scientists concluded there is “clear evidence” linking cell phone radiation to the development of cancers in rats. The U.S. government invited an expert panel to make a majority-rules declaration in response to the $25 million U.S. government National Toxicology Program (NTP) study of cell phone radiation in animals. After a three-day review of the study data, they voted to strengthen the conclusions that cell phone radiation caused health effects in the cell phone radiation exposed rats and mice.
Scientific American and The Nation both ran stories on the issue along with The News and Observer entitling their piece, “Can your cellphone cause cancer? Scientists find definitive link in study of rats.” Ira Flatow of Science Friday also featured the scientific conference findings in a radio interview “Is There A Cell Phone Link To Cancer? A Definite Maybe” on March 30, 2018.
The National Institute of Environmental Health Sciences (NIEHS), National Toxicology Program released a statement about the conclusions of the panel for each endpoint, found here. NIEHS also wrote an article on the March conclusions of “clear evidence” in an article entitled, “NTP cell phone studies — experts recommend elevated conclusions.” See the presentation by NIEHS on DNA damage found in rats and mice.
同行评审小组投票认为，雄性大鼠心脏中发现的恶性神经鞘瘤在科学上被归类为“致癌性的明确证据”，并且在雄性大鼠脑中发现的恶性神经胶质瘤被归类为“某些致癌性证据”。 此外，他们投票认为暴露于GSM类型手机辐射的雄性大鼠肾上腺髓质肿瘤增加被归类为“致癌性的一些证据”，并增加了一种被认为是由暴露引起的新型肿瘤。 专家小组建议加强有关七种不同健康影响的结论。 该小组提请注意暴露的雄性和雌性大鼠中心脏病的不寻常模式或心脏组织损伤的统计学显着增加。 该小组强调，在意大利，最近一项关于射频辐射的动物研究报告的辐射水平远低于NTP研究，发现了相同类型的罕见恶性肿瘤。
The peer review panel voted that the malignant schwannoma tumors found in the heart of male rats be scientifically categorized as “clear evidence of carcinogenicity” and that the malignant gliomas found in the brain of male rats be categorized as “some evidence of carcinogenicity.” In addition, they voted that the increased tumors of the adrenal medulla in male rats exposed to the GSM type of cell phone radiation be categorized as “some evidence of carcinogenicity,” adding a new type of tumor thought to be caused by the exposure. The expert panel advised strengthening the conclusions regarding seven different health effects. The panel called attention to statistically significant increases in an unusual pattern of cardiomyopathy, or damage to heart tissue, in exposed male and female rats. The panel highlighted that in Italy a recent animal study on radiofrequency radiation at much lower radiation levels than the NTP study found the same types of rare malignancies.
In addition to the heart and brain cancers, statistically significant increased numbers of tumors were found in other organs at one or more of the exposure levels studied, including the prostate gland, pituitary gland, adrenal gland, liver, and pancreas. See the bottom of this release for a full list of cancer endpoints.
“现在应该发生的事情是FDA应该立即开始从这些数据开发定量风险评估，同时FDA，FCC和其他机构应该为人群特别是儿童推广预防措施，”Ronald Melnick博士说。 他在国家毒理学项目中担任科学家28年的职业生涯，领导了NTP研究的设计。 Melnick目前是Environmental Health Trust（EHT）的高级顾问。
“What should happen now is the FDA should be immediately working on developing a quantitative risk assessment from this data and in the meantime the FDA, FCC, and other agencies should promote precautionary measures for the population—especially for children,” said Ronald Melnick PhD, who led the design of the NTP study in his 28-year career as a scientist at the National Toxicology Program. Melnick is currently senior advisor to Environmental Health Trust (EHT).
“足够了，在采取严肃行动之前还需要多少人死亡？ 证据不断积累。 2018年3月28日，国家毒理学计划的外部同行评审员投票决定增加射频辐射对几种肿瘤和其他负面健康影响的因果作用的证据水平。 现在是采取行动的时候了，“世界卫生组织国际癌症研究机构癌症预防流行病学研究部前负责人，医学博士，医学博士，前任主任，医学博士。
“Enough is enough, how many more deaths would be needed before serious action is taken? Evidence just continues to accumulate. On March 28, 2018, the external peer reviewers of the National Toxicology Program voted to increase the level of evidence for the causal role of radiofrequency radiation for several tumors and other negative health effects. It’s time for action,” commented Annie Sasco MD, DrPH, former Chief of Research Unit of Epidemiology for Cancer Prevention at the International Agency for Research on Cancer of the World Health Organization and medical advisor to EHT.
“NTP研究发现远远超过癌症的证据。在他们的一生中暴露于人类可以接收的相同辐射量的动物产生了更小的婴儿，他们的心脏有更多的缺陷。同样令这些结果特别引人注目的是，所有精心设计的对10年或更长时间暴露于手机的人的研究都发现了类似肿瘤 – 胶质瘤和听神经瘤的风险。然而，在这个国家的学校和家庭中，每天的暴露量持续增加，因为儿童可以使用双向微波辐射装置在他们年轻的发育机构旁边使用，“希伯来大学医学院客座教授，公共卫生硕士Devra Davis博士说。环境健康信托基金会补充说：“本周在环境研究中发表的Ramazzini研究发现，与国家毒理学计划研究中发现的同样罕见的癌症有统计学意义上的显着增加，但辐射水平显着低于NTP。综合起来，这两项研究强化了这种辐射是致癌物的情况。迫切需要采取警戒行动，以减少儿童和我们其他人的暴露。微软加拿大前总裁弗兰克克莱格的业务咨询小组主席告诉我：“我来自智能行业。告诉我们我们需要做什么，我们会完成它。’“
“The NTP study found far more than evidence of cancer. Animals exposed in their lifetimes to the same amount of radiation that a human can receive in theirs gave birth to smaller babies with more defects in their hearts. What also makes these results especially compelling is the fact that all well-designed studies of people with 10 or more years of exposures to cell phones find higher risks for comparable tumors—gliomas and acoustic neuromas. Yet exposures continue to increase every day in schools and homes throughout this nation as children are handed two-way microwave radiating devices to use next to their young developing bodies,” stated Devra Davis PhD, MPH, Visiting Professor of Medicine at Hebrew University and President of Environmental Health Trust, who added, “the Ramazzini Study published this week in Environmental Research found statistically significant increases of the same rare cancers as found in the National Toxicology Program study, but at radiation levels significantly lower than those of the NTP. Combined, these two studies strengthen the case that this radiation is a carcinogen. Cautionary action is urgently needed to reduce exposures for children and the rest of us. The chairman of our Business Advisory Group Frank Clegg, former President of Microsoft Canada, has advised: ‘I come from a smart industry. Tell us what we need to do and we will get it done.’”
这一动物证据，以及广泛的人类证据表明暴露于长时间射频辐射的人脑和前庭神经鞘瘤的风险增加，主要来自手机，特别是如果暴露于年轻时，同时发病率上升 美国年轻人患有脑癌，最终证实射频辐射是第1类人类致癌物，“多伦多大学Dalla Lana公共卫生学院名誉教授，EHT医学顾问Anthony Miller医学博士解释说，他曾担任过EHT的医学顾问。 世界卫生组织的顾问。
This animal evidence, together with the extensive human evidence showing increased risk of gliomas of the brain and vestibular schwannomas in humans exposed to prolonged radiofrequency radiation, largely from cell phones, especially if the exposure begins at a young age, coupled with a rising incidence of brain cancers in young people in the U.S., conclusively confirms that radiofrequency radiation is a Category 1 human carcinogen,” explains Anthony Miller MD, Professor Emeritus, Dalla Lana School of Public Health, University of Toronto, medical advisor to EHT, who has served as an advisor to the World Health Organization.
“同行评审员在一个透明的科学过程中审查了肿瘤数据。 除了最近发布的意大利Ramazzini研究之外，这项具有里程碑意义的美国政府研究提供了政府需要采取迅速行动保护公众的科学证据，“EHT执行董事Theodora Scarato补充道，”推出5G小细胞 必须停止。 学校需要安装有线互联网。 社区应该保持固定电话。 存在诸如以太网和光纤网络的解决方案。 公共卫生部门需要开展公众意识活动，教育公众如何减少接触。 人们需要了解使用有线连接而不是无线辐射是多么容易，尤其是在家中。 雇主需要优先处理此问题并在工作场所进行更改，以限制和最小化工作场所暴露。 我们现在有责任就此问题采取行动。“
“The peer reviewers reviewed the tumor data in a transparent scientific process. This landmark U.S. government study, in addition to the recently released Italian Ramazzini study, provides the scientific evidence governments need to take swift action to protect the public,” said Theodora Scarato, Executive Director of EHT who added, “The rollout of 5G small cells must be halted. Schools need to install wired internet networks. Communities should have maintained landlines. Solutions exist such as Ethernet and fiber optic networks. Public Health Departments need to initiate public awareness campaigns to educate the public on how to reduce exposure. People need to understand just how easy it is to use wired connections, instead of wireless radiation, especially at home. Employers need to prioritize this issue and make changes in the workplace to limit and minimize workplace exposures. We have a responsibility to take action on this issue now.”
Marc Arazi博士表示，他从法国出发前往4000英里，告诉国家毒理学计划的科学家，手机进行辐射测试的方式并不能反映真实的人体暴露，他们使用的暴露水平是可比的，实际上低于辐射照射人可以通过手机使用体验。 “就实际使用而言，我们几乎所有的手机都使我们的暴露水平比法规允许的保护我们健康的限制高出2到10倍。我这是基于2012年至2016年由法国国家频率机构对欧洲近400种最畅销的手机进行的政府辐射测试。这个问题是国际健康和工业丑闻的起源，称为Phonegate。法国测试中发现的辐射测量值远远超过NTP研究中使用的暴露水平。我在同行评审会议期间在研究的作者和专家组的科学家面前公开展示了这些启示。我很高兴听到NTP的John Bucher博士向记者解释如何通过将手机与身体保持一定距离来减少辐射暴露。
Dr. Marc Arazi stated that he traveled from France 4000 miles to tell the National Toxicology Program scientists that the way cell phones are radiation tested do not reflect real human exposure and that the exposure levels they used are comparable and in fact lower than radiation exposures people can be experiencing from cell phone use. “In terms of actual use, almost all of our mobile phones expose us to levels 2 to 10 times higher than the limits allowed by the regulations to protect our health. I say this based on government radiation tests conducted between 2012 and 2016 by the French National Frequencies Agency on nearly 400 of the best-selling mobile phones in Europe. This issue is at the origin of the international health and industrial scandal called Phonegate. The radiation measurements found in the French tests far exceed the exposure levels used in the NTP study. I presented these revelations publicly during the Peer Review session in front of the authors of the study and the scientists of the pane. I was pleased to hear Dr. John Bucher of the NTP explain to reporters how to reduce radiation exposure by keeping the phone at a distance from the body.
“这是我们理解中向前迈出的重要一步。 但根据我的判断，NTP研究大大低估了风险。 这是因为他们使用了混响曝光室，它降低了电磁场的极化并且还可以产生大量的破坏性干扰。 这两项变化都会降低生物效应，“华盛顿州立大学生物化学与基础医学荣誉教授Martin Pall博士说。
“This is an important step forward in our understanding. But the NTP study, in my judgement substantially underestimates the risk. That is because they used a reverberation exposure chamber which lowers the polarization of the electromagnetic field and can also produce substantial amounts of destructive interference. Both of these changes decrease biological effects,” stated Martin Pall, PhD, Professor Emeritus of Biochemistry and Basic Medical Sciences, Washington State University.
“来自无线设备的RFR似乎是一种常见的毒性暴露，类似于其他化学毒素和金属。 在这个日益无线的环境中，更多的人将患上慢性病。 需要几十年的时间（如果可能的话）来理清无线技术带来的伤害的附加贡献。 您的研究表明，指南需要基于生物细胞效应，而不是热效应。 有必要采取预防措施。 减少暴露于RFR是一种预防性的公共卫生措施，“医学安全技术医学博士，”学校Wi-Fi“和”5G无线未来：它将给我们一个聪明的国家或有贡献的作者“的Cindy Russell说。 一个不健康的人？“
“RFR from wireless devices appears to act as a common toxic exposure similar to other chemical toxins and metals. In this increasingly wireless environment, more people will be developing chronic diseases. It will take decades (if it is even possible) to sort out the additive contribution of harm from wireless technology. Your research indicates that guidelines need to be based on biological cellular effects and not thermal effects. Precaution is warranted. Reduction of exposure to RFR is a preventative public health measure,” stated Cindy Russell, MD of Physicians For Safe Technology and author of “Wi-Fi in Schools” and “A 5G Wireless Future: Will It Give Us a Smart Nation or Contribute to An Unhealthy One?”.
The National Institute of Environmental Health Sciences webcast of the three-day review will be online within days. The NIEHS meeting webpage with powerpoint slide presentations is here.
RECOMMENDATIONS OF CLASSIFICATION OF CANCERS AND PRE CANCERS in NTP STUDY
On March 26-28, 2018 the NTP expert peer review panel recommended the following actions related to the strength of confidence in the association between the finding and the exposure- NTP’s scale of clear evidence, some evidence, equivocal evidence, and no evidence. For seven cancer endpoints, the peer review recommendations were to increase the level of evidence (noted with a *) They recommended the following strength of evidence classifications after a review of the study findings.
Clear Evidence of Carcinogenic Activity
- *Increases in malignant schwannoma in the heart in male rats (GSM and CDMA) – clear evidence of carcinogenic activity
Some Evidence of Carcinogenic Activity: The strength of the response is less than that required for clear evidence but is enough to consider it an association.
- * malignant glioma in the brain in male rats (GSM and CDMA) – some evidence of carcinogenic activity
- *Increases in pheochromocytoma (benign, malignant, or complex combined) in the adrenal medulla male rats (GSM) – some evidence of carcinogenic activity
Equivocal Evidence of Carcinogenic Activity: A marginal increase of neoplasms that may be related to the exposure.
- Increases in adenoma or carcinoma (combined) in the prostate gland in male rats (GSM and CDMA) – equivocal evidence of carcinogenic activity
- Increases in benign or malignant granular cell tumors in the brain in male rats (GSM) equivocal evidence of carcinogenic activity
- Increases in adenoma in the pars distalis of the pituitary gland in male rats exposed to both GSM and CDMA – equivocal evidence of carcinogenic activity
- Increases in adenoma in the pars distalis of the pituitary gland in male rats CDMA – equivocal evidence of carcinogenic activity
- Increases in pancreatic islet cell adenoma or carcinoma in male rats (GSM) -equivocal evidence of carcinogenic activity
- * Increases in malignant schwannomas in the heart in female rats GSM and CDMA –equivocal evidence of carcinogenic activity
- Increases in malignant glioma in the brain in female CDMA- equivocal evidence of carcinogenic activity
- Increases in pheochromocytoma (benign, malignant, or complex combined) in the adrenal medulla in female rats (CDMA) – equivocal evidence of carcinogenic activity
- DNA damage was significantly increased in the frontal cortex of male mice (both modulations GSM and CDMA), peripheral leukocytes of female mice (CDMA only), and hippocampus of male rats (CDMA only). “These results suggest that exposure to RFR has the potential to induce measurable DNA damage under certain exposure conditions,” stated the NTP scientists in this PDF of the Genotoxicity findings.
- Cardiomyopathy of the right ventricle in both male and female exposed animals in both CDMA and GSM.
- Increases in nonneoplastic lesions in the heart, brain, and prostate gland in male rats (GSM and CDMA).
- Increases in nonneoplastic lesions in the heart, thyroid gland, and adrenal gland in female rats occurred with exposures to GSM.
- Increases in nonneoplastic lesions of the brain in females exposed to CDMA.
* Peer reviewers increased the level of strength of evidence from the draft report.
Click here to download and share an infographic about cell phone radiation and cancer.
Environmental Health Trust has compiled key documents and resources so you get the information you need about the National Toxicology Program Study findings.
National Toxicology Program Cell Phone Radiation Study Documents
“NTP cell phone studies — experts recommend elevated conclusions “ NIEHS published article on the “clear evidence” of cancer conclusions of the peer review.
“Statement of the Conclusions of the NIEHS Peer Review” The NIEHS NTP issued this two page document that lists the final conclusions of the peer review panel for each cancer endpoint.
Full report/presentation by NIEHS on DNA damage found in rats and mice. Note: This information was presented in 2017 at a conference and found via a public information request.
The Peer Review panel of experts for the NTP technical Report See it here
National Institute of Health Press Materials
2/1/2018 NIEHS Press Release “High Exposure to Radiofrequency Radiation Linked to Tumor Activity in Male Rats”