姜黄为口腔癌提供了潜在的治疗方法 Curcumin/turmeric offers potential therapy for oral cancers

治疗和姜黄素 – 姜黄为口腔癌提供了潜在的治疗方法

咖喱成分减缓口腔癌细胞中的HPV病毒

根据ecancermedicalscience发表的最新研究,姜黄 – 印度和亚洲烹饪中常见的黄色香料 – 可能在与人乳头瘤病毒相关的口腔癌中发挥治疗作用。

草药的一种主要活性成分 – 一种叫做姜黄素的抗氧化剂 – 似乎对人乳头瘤病毒(HPV)的活性产生了抑制作用。

HPV是一种促进宫颈癌和口腔癌发展的病毒。没有治愈方法,但姜黄素可能提供未来控制的手段。

“姜黄已经建立了抗病毒和抗癌特性,”相应的作者,美国亚特兰大埃默里大学的Alok Mishra博士说。 “根据我们的新发现,我们可以说它对口腔健康也有好处。”

Mishra博士的研究小组首次注意到姜黄素在2005年对HPV和宫颈癌细胞的影响。抗氧化剂减缓了HPV的表达,表明姜黄素可以控制HPV感染的程度。

“由于HPV相关的口腔癌病例正在上升,我们对口腔癌的相同假设进行了测试,”Mishra博士说。

“他们发现了一些非常有趣的发现。”

新的研究表明,姜黄素通过下调细胞转录因子AP-1和NF-kB的水平,降低感染的口腔癌细胞中HPV的表达。

这些发现可能表明cucurmin在癌症控制中具有新的治疗作用。

虽然米什拉博士无法评论姜黄在烹饪中的治疗益处,但他表示使用姜黄和其他抗氧化剂可能对健康有益,特别是与HPV相关的口腔癌。

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Cures and curcumin — turmeric offers potential therapy for oral cancers

Curry ingredient slows HPV virus in oral cancer cells

ecancermedicalscience

Turmeric – the familiar yellow spice common in Indian and Asian cooking – may play a therapeutic role in oral cancers associated with human papillomavirus, according to new research published in ecancermedicalscience.

One of the herb’s key active ingredients – an antioxidant called curcumin – appears to have a quelling effect on the activity of human papillomavirus (HPV).

HPV is a virus that promotes the development of cervical and oral cancer. There is no cure, but curcumin may offer a means of future control.

“Turmeric has established antiviral and anti-cancer properties,” says corresponding author Dr Alok Mishra of Emory University, Atlanta, USA. “And according to our new findings, we could say that it’s good for oral health too.”

Dr Mishra’s research group first noted the effect of curcumin on HPV and cervical cancer cells in 2005. The antioxidant slowed the expression of HPV, suggesting that curcumin could control the extent of HPV infection.

“Since HPV-related oral cancer cases are on the rise, we tested the same hypothesis on oral cancer,” Dr Mishra says.

“They turned out to be some very interesting findings.”

The new research indicates that curcumin turns down the expression of HPV in infected oral cancer cells by downregulating the levels of cellular transcription factors AP-1 and NF-kB.

These findings could suggest a new therapeutic role for cucurmin in cancer control.

While Dr Mishra cannot comment on the therapeutic benefits of turmeric in cooking, he says that the use of turmeric and other anti-oxidants may be good for health in general, and HPV-related oral cancers in particular.

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