维生素D和鱼油有助于预防癌症死亡和心脏病 Vitamin D and fish oil show promise in prevention of cancer death and heart attacks

VITamin D和OmegA-3试验(VITAL)是规模最大且最新的试验,旨在测试维生素D或鱼油能否有效预防癌症或心血管疾病。迄今为止,结果参差不齐,但对某些结果显示出希望,现在已通过更新的汇总分析得到证实。 VITAL的最新结果将在2019年9月25日至28日在芝加哥举行的北美更年期协会(NAMS)年会上发表。

近26,000名美国男人和女人参加了全国性的VITAL临床试验。经过五年多的研究和治疗,结果显示出某些结果有希望的信号。例如,虽然Omega-3脂肪酸(鱼油)在主要CVD事件的主要心血管终点中显示了少量的减少,但它们与心脏病发作的显着减少有关。在饮食鱼类摄入量低于队列每周中位数1.5份食物的人群中,可以看到最大的治疗益处,但在摄入量高于该水平的人群中则没有。此外,非洲裔美国人似乎最大程度地降低了风险。近期对omega-3随机试验的荟萃分析证实了心脏健康的益处。

同样,在至少两年的试验中,补充维生素D并不能减少主要的CVD事件或总癌症发生率,但与总癌症死亡率的统计显着降低有关。迄今为止,最新的维生素D试验荟萃分析也证实了维生素D在减少癌症死亡中的作用。

NEWS RELEASE 

Vitamin D and fish oil show promise in prevention of cancer death and heart attacks

Upcoming presentation to provide updates on VITAL clinical trial showing mixed results of how vitamin D and Omega-3 fatty acids help protect against cancer mortality and myocardial infarction

THE NORTH AMERICAN MENOPAUSE SOCIETY (NAMS)

CLEVELAND, Ohio (September 24, 2019)–The VITamin D and OmegA-3 Trial (VITAL) is the largest and most recent to test whether vitamin D or fish oil can effectively prevent cancer or cardiovascular disease. Results to date have been mixed but show promise for some outcomes, now confirmed by updated pooled (meta) analyses. The latest results from VITAL will be presented during The North American Menopause Society (NAMS) Annual Meeting in Chicago, September 25-28, 2019.

Nearly 26,000 U.S. men and women participated in the nationwide VITAL clinical trial. After more than five years of study and treatment, the results show promising signals for certain outcomes. For example, while Omega-3 fatty acids (fish oil) showed only a small, but nonsignificant, reduction in the primary cardiovascular endpoint of major CVD events, they were associated with significant reductions in heart attacks. The greatest treatment benefit was seen in people with dietary fish intake below the cohort median of 1.5 servings per week but not in those whose intake was above that level. In addition, African-Americans appeared to experience the greatest risk reductions. The heart health benefits are now confirmed by recent meta-analyses of omega-3 randomized trials.

Similarly, vitamin D supplementation did not reduce major CVD events or total cancer incidence but was associated with a statistically significant reduction in total cancer mortality among those in the trial at least two years. The effect of vitamin D in reducing cancer death is also confirmed by updated meta-analyses of vitamin D trials to date.

“The pattern of findings suggests a complex balance of benefits and risks for each intervention and points to the need for additional research to determine which individuals may be most likely to derive a net benefit from these supplements,” says Dr. JoAnn Manson, lead author of the study from Brigham and Women’s Hospital, an affiliate of Harvard Medical School.

“With heart disease and cancer representing the most significant health threats to women, it is imperative that we continue to study the viability of options that prevent these diseases and help women survive them,” says Dr. Stephanie Faubion, NAMS medical director.

Drs. Manson and Faubion are available for interviews before the presentation at the Annual Meeting.

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