Vitamin C helps prevent and treat leukemia 维生素C帮助预防和治疗白血病

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Leukemia seems to be harder to treat than solid cancer. And more and more people are getting the disease in China these years. So it is important to learn to prevent the disease from developing.

One risk for leukemia is vitamin C deficient. Studies showed low levels of serum vitamin C makes people more susceptible to leukemia. And this deficiency is easy to overcome.

Scientists at University of Texas Southwestern Medical Center reported the journal Nature that vitamin C helps to slow the development of leukemia. This is done by re-activating an enzyme that stops leukemia cell from growing and spreading.

Vitamin C also known as ascorbic acid at high levels helps stem cells to function properly. When stem cells are depleted of vitamin C, the epigenome of stem cells is impaired and could not control genes properly. This impairs stem cell function and raises the risk of leukemia.

Vitamin D deficiency also limits levels of TET2, an enzyme that help stem cells generate mature white blood cells. Mutations in genes responsible for the enzyme can lead to deactivation of the enzyme. This will cause uncontrollable cell division, that is, cells never mature and do not die at the proper time.

The inactivation of this enzyme can eventually lead to the development of leukemia.

Good news is, when an optimal level of vitamin C is used, the gene is re-activated and the enzyme is produced at a maximal rate. At the optimal rate, the TET1 tumor suppressor activity is maximized. That slows the growth of leukemia.

High levels of vitamin C are particularly important for older individuals with clonal hematoiesis or a form of -pre-leukemia. Patients with this condition are often found to carry a mutation in the TET gene.

TET2 mutations are responsible for 42,500 cancers in the U.S. each year. Half of the patients with chronic myelomonocytic leukemia, 30% pre-leukemia and 10% acute myeloid leukemia patients have TET2 mutations.

A mouse study published in Cell found reducing TET2 activity by 50% could induce malignancy or cancer. Good news is, six months of daily high dose vitamin C supplementation can genetically restore TET2 to full capacity. This full TET2 activity stops leukemia cells from reproducing and kills them completely.

When used along with PARP inhibitors, vitamin C substantially improved the efficacy of the pharmaceutical drugs against the cancer.

The effective dose is 300,000 milligrams for humans. This dose can only be delivered through IV injection.

Vitamin C works as a pro-oxidant in cancer cells to deplete stores of the antioxidant glutathione and cause oxidative stress and kill cancer cells. Vitamin C also disrupts glycolysis, the biochemical process that produces energy in cancer cell mitochondria.

High levels of vitamin C also decrease inflammation in cancer patients. When used in patients who are receiving conventional treatments like chemotherapy and radiation therapy, vitamin C can improve the quality of life. It suppresses symptoms of fatigue, nausea, vomiting, and pain and appetite loss associated with cancer treatment.

Animal studies also indicate high dose of vitamin C treatment blocks tumor growth of patients with pancreatic cancer, liver cancer, prostate cancer and ovarian cancers.

Good thing with vitamin C is, is does not affect healthy cells. High doses of vitamin C lead to few side effects.

Vitamin C improves many other conditions including high blood pressure, gallbladder, disease, stroke, and atherosclerosis. Holistic practitioners recommend supplementation with 10 to 12 grams of vitamin C a day.

Eating raw vegetables like bell peppers, kiwi, grapefruit, and strawberries can boost the dietary vitamin C intake. But diet cannot provide too much of vitamin C. So vitamin C supplements are needed. (Dr Lu)

白血病似乎比实体癌更难治疗。这些年来,越来越多的人在中国患上该病。因此,重要的是要学会预防疾病的发展。

白血病的一种风险是维生素C缺乏。研究表明,血清维生素C含量低使人们更容易患白血病。而且这种缺陷很容易克服。

德克萨斯大学西南医学中心的科学家们在《自然》杂志上报道,维生素C有助于减缓白血病的发展。这可以通过重新激活阻止白血病细胞生长和扩散的酶来完成。

高水平的维生素C也称为抗坏血酸,有助于干细胞正常运行。当干细胞缺乏维生素C时,干细胞的表观基因组就会受损,无法正确控制基因。这会损害干细胞功能并增加患白血病的风险。

维生素D缺乏症还限制了TET2的水平,该酶可帮助干细胞生成成熟的白细胞。负责该酶的基因突变会导致该酶失活。这将导致无法控制的细胞分裂,即细胞永远不会成熟,并且不会在适当的时间死亡。

该酶的失活最终可导致白血病的发展。

好消息是,当使用最佳水平的维生素C时,该基因会重新激活,并以最大速率产生酶。以最佳速率,TET1肿瘤抑制活性最高。这减慢了白血病的生长。

维生素C的高含量对于患有克隆性造血或白血病前期形式的老年人尤其重要。通常发现患有这种疾病的患者携带TET基因突变。

TET2突变每年在美国造成42,500例癌症。一半的慢性粒细胞性白血病,30%的白血病前期患者和10%的急性髓细胞性白血病患者具有TET2突变。

在《细胞》杂志上发表的一项小鼠研究发现,将TET2活性降低50%可能会诱发恶性肿瘤或癌症。好消息是,每天补充六个月的高剂量维生素C可以使TET2基因恢复至完全容量。这种完全的TET2活性可阻止白血病细胞繁殖并完全杀死它们。

当与PARP抑制剂一起使用时,维生素C大大改善了药物抗癌的功效。

对人的有效剂量为300,000毫克。该剂量只能通过静脉注射来递送。

维生素C在癌细胞中起促进氧化剂的作用,耗尽了抗氧化剂谷胱甘肽的储存并引起氧化应激并杀死癌细胞。维生素C还破坏糖酵解,糖酵解是在癌细胞线粒体中产生能量的生化过程。

高水平的维生素C还可以减少癌症患者的炎症。当用于接受化学疗法和放射疗法等常规治疗的患者时,维生素C可以改善生活质量。它可以抑制与癌症治疗相关的疲劳,恶心,呕吐,疼痛和食欲不振的症状。

动物研究还表明,高剂量的维生素C治疗可阻止胰腺癌,肝癌,前列腺癌和卵巢癌患者的肿瘤生长。

维生素C的好处是,不会影响健康细胞。高剂量的维生素C几乎没有副作用。

维生素C可改善许多其他状况,包括高血压,胆囊,疾病,中风和动脉粥样硬化。整体医生建议每天补充10至12克维生素C。

吃青椒,猕猴桃,葡萄柚和草莓等生蔬菜可以增加饮食中维生素C的摄入量。但是饮食不能提供过多的维生素C。因此需要补充维生素C。 (陆博士)

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