促炎的饮食与结直肠癌的风险相关 An inflammatory diet correlates with colorectal cancer risk

Bellvitge生物医学研究所(IDIBELL)和加泰罗尼亚肿瘤研究所(ICO)的肿瘤学分子机制和实验治疗计划(Oncobell)以及Biodonostia健康研究所(IIS Biodonostia)等研究人员已发表在Nutrients中,一项多中心研究的结果揭示了炎症和抗氧化饮食之间的相关性以及患结直肠癌和乳腺癌的风险。来自IDIBELL-ICO的MireiaObón-Santacana博士是由IIS Biodonostia首席研究员Pilar Amiano博士和IDIBELL-ICO结直肠癌研究小组负责人VíctorMoreno博士领导的研究的第一作者。由于西班牙抗癌协会(AECC)提供的资金,部分研究成为可能。

“我们观察到发生结直肠癌的风险与饮食的炎症潜能之间存在关联。也就是说,接种炎症饮食的参与者患结直肠癌的风险几乎是全世界第四大癌症的风险,这是全球第四大癌症。” ,MireiaObón博士解释说。 “另一方面,我们还没有意识到乳腺癌风险的显着增加。这就是为什么我们需要进行更多研究以检查是否与其他因素确实存在任何相关性”,她补充道。

炎症性饮食通常以精制碳水化合物,红色和加工肉类以及饱和脂肪或反式脂肪的消耗为特征。在抗氧化饮食中,蔬菜,豆类,水果和坚果的消费占主导地位。 “在这项研究中,我们专注于饮食的作用,特别是其炎症和抗氧化能力,因为有证据表明慢性炎症和氧化应激都会影响这两种癌症的发展”,VíctorMoreno博士说。

MireiaObón博士强调,“促炎和促氧化饮食是结肠癌的一个非常重要的危险因素。积极的一面是,这是一个可以改变的因素,因此可以改变”。 “因此,为了预防此类癌症,遵循官方机构和国际机构的建议非常重要。我们应该将饮食习惯调整为地中海饮食,富含水果和蔬菜,坚果,全谷物和健康油脂, 如橄榄油和远离更促炎的饮食“。

IDIBELL-ICO研究员建议的是“实施营养和健康专业人员创建的教育策略,以便普通人群能够遵循饮食建议并改变他们的习惯”。

在这项新的研究中,科学家通过膳食炎症指数(DII)和非酶抗氧化能力(NEAC)专门分析了西班牙人群,这是评估饮食中炎症和抗氧化潜力的两种有用和有效的工具。为了进行这项研究,纳入了1852例结直肠癌和1567例乳腺癌,分别为3447例和1487例对照病例。该研究借鉴了12个西班牙省份的数据。

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NEWS RELEASE 

An inflammatory diet correlates with colorectal cancer risk

The risk of developing colorectal cancer for individuals that follow a pro-inflammatory diet is two times higher than usual

IDIBELL-BELLVITGE BIOMEDICAL RESEARCH INSTITUTE

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IMAGE: DR. VICTOR MORENO (LEFT) AND DR. MIREIA OBÓN (NEXT TO HIM). view more 

CREDIT: GEMMA CASTAÑO-VINYALS

Researchers from the Molecular Mechanisms and Experimental Therapy in Oncology program (Oncobell) of the Bellvitge Biomedical Research Institute (IDIBELL) and the Catalan Institute of Oncology (ICO), together with the Biodonostia Health Research Institute (IIS Biodonostia), among others, have published in Nutrients the results of a multicenter study that unveils a correlation between inflammatory and antioxidant diets and the risk of developing colorectal and breast cancer. Dr. Mireia Obón-Santacana from IDIBELL-ICO is the first author of a research which was led by Dr. Pilar Amiano, principal investigator at IIS Biodonostia, and Dr. Víctor Moreno, head of the colorectal cancer research group at IDIBELL-ICO. Part of the study has been possible thanks to the funding provided by the Spanish Association Against Cancer (AECC).

“We have observed an association between the risk of developing colorectal cancer and the inflammatory potential of the diet. That is, the participants who followed an inflammatory diet had almost twice the risk of developing colorectal cancer, which is the 4th most frequent cancer worldwide”, explains Dr. Mireia Obón. “On the other hand, we have not appreciated a significant increase in breast cancer risk. That is why we need to carry out more studies to check if there is really any correlation with other factors”, she adds.

An inflammatory diet is usually characterized by the consumption of refined carbohydrates, red and processed meat, and saturated or trans fats. In an antioxidant diet, the consumption of vegetables, legumes, fruits and nuts predominates. “In this study we have focused on the role of diet, and specifically on its inflammatory and antioxidant capacity, as there is evidence that both chronic inflammation and oxidative stress influence the development of these two types of cancer”, says Dr. Víctor Moreno.

“Following a pro-inflammatory and pro-oxidant diet is a very important risk factor for colon cancer. The positive part is that this is a modifiable factor and, therefore, it can be changed”, underlines Dr. Mireia Obón. “Therefore, in order to prevent such cancers, it is very important to follow the recommendations of official agencies and international agencies. We should reorient our eating habits towards a Mediterranean diet, rich in fruits and vegetables, nuts, whole grains and healthy oils, such as olive oil and move away from a more pro-inflammatory diet”, she argues.

What the IDIBELL-ICO researcher suggests is to “implement education strategies created by nutrition and health professionals, so that the general population can follow dietary recommendations and change their habits”.

In this new study, scientists have specifically analysed the Spanish population through the Dietary Inflammatory Index (DII) and the Non-Enzymatic Antioxidant Capacity (NEAC), which are two useful and validated tools to estimate the inflammatory and the antioxidant potential of the diet. To carry out the study, 1852 cases of colorectal cancer and 1567 cases of breast cancer were included, together with 3447 and 1487 control cases, respectively. The study drew on data from 12 Spanish provinces.

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