肥胖母亲所生的孩子更有可能在儿童早期患上癌症 Maternal obesity linked to childhood cancer

匹兹堡大学公共卫生研究生院和UPMC希尔曼癌症中心的一项新研究发现,肥胖母亲所生的孩子更有可能在儿童早期患上癌症。

利用宾夕法尼亚州的出生记录,研究人员发现母亲的孕前体重指数(BMI)与其后代的癌症诊断之间存在相关性,即使在纠正已知的危险因素(如新生儿大小和母亲年龄)之后也是如此。该论文的最终版本今天在线发表在“美国流行病学杂志”上。

“目前,我们还不知道儿童癌症的许多可避免的危险因素,”主要作者,皮特公共卫生部流行病学博士和UPMC希尔曼癌症中心的博士后学者Shaina Stacy博士说。 “我希望这项研究能够在某种程度上增强力量并激励减肥。”

Stacy及其同事在2003年至2016年间在宾夕法尼亚州提交了近200万份出生记录和约3,000份癌症登记记录,发现严重肥胖母亲所生的孩子 – 体重指数高于40岁 – 之前发生白血病的风险高出57%。年龄5.体重和身高也与白血病风险增加有关。

进一步的分析表明,不仅仅是更大的女性生下更大的婴儿,或者更重的女性往往是年龄较大的儿童癌症的危险因素 – 而是母亲的大小独立地影响了她孩子的风险。

研究人员认为,他们所看到的效果的根本原因与胎儿发育过程中母亲体内的胰岛素水平有关,或者可能是母亲DNA表达的变化传递给了她的后代。

重要的是,并非所有级别的肥胖都具有相同的风险。在该研究中的肥胖女性中,较高的BMI伴随着孩子的癌症发病率较高。因此,即使少量的减肥也可以转化为风险的真正降低,Stacy说。

“我们正在处理这个国家的肥胖流行病”,资深作者,医学博士,医学博士,皮特公共卫生学流行病学教授,UPMC希尔曼癌症癌症流行病学和预防项目的联合负责人说。中央。 “从预防的角度来看,保持健康的体重不仅有利于母亲,也有利于儿童。”

NEWS RELEASE 

Maternal obesity linked to childhood cancer

UNIVERSITY OF PITTSBURGH

PITTSBURGH, July 10, 2019 – A new study from the University of Pittsburgh Graduate School of Public Health and UPMC Hillman Cancer Center found that children born to obese mothers were more likely to develop cancer in early childhood.

Using Pennsylvania birth records, the researchers found a correlation between pre-pregnancy body-mass index (BMI) in mothers and subsequent cancer diagnosis in their offspring, even after correcting for known risk factors, such as newborn size and maternal age. The final version of the paper published online today in the American Journal of Epidemiology.

“Right now, we don’t know of many avoidable risk factors for childhood cancer,” said lead author Shaina Stacy, Ph.D., postdoctoral scholar in the Pitt Public Health Department of Epidemiology and UPMC Hillman Cancer Center. “My hope is that this study can be, in a way, empowering and also motivating for weight loss.”

Stacy and colleagues pored through nearly 2 million birth records and about 3,000 cancer registry records filed in the state of Pennsylvania between 2003 and 2016 and found that children born to severely obese mothers–BMI above 40–had a 57% higher risk of developing leukemia before age 5. Weight and height also were individually associated with increased leukemia risk.

Further analysis showed that it wasn’t simply that larger women were giving birth to larger babies or that heavier women tended to be older–known risk factors for childhood cancer–but rather, a mother’s size independently contributed to her child’s risk.

The researchers think the root cause of the effect they’re seeing has something to do with insulin levels in the mother’s body during fetal development, or possibly changes to the mother’s DNA expression that are passed to her offspring.

Importantly, not all levels of obesity carry the same risk. Among the obese women in the study, higher BMI came with higher cancer rates in their children. So, even small amounts of weight loss can translate to a real reduction in risk, Stacy said.

“We are dealing with an obesity epidemic in this country,” said senior author Jian-Min Yuan, M.D., Ph.D., professor of epidemiology at Pitt Public Health and co-leader of the cancer epidemiology and prevention program at UPMC Hillman Cancer Center. “From a prevention point-of-view, maintaining a healthy weight is not only good for the mother, but also for the children, too.”

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Additional authors on the study include Jeanine Buchanich, M.Ed., M.P.H., Ph.D., Christina Mair, Ph.D., Ravi Sharma, Ph.D., and Evelyn Talbott, Dr.P.H., M.P.H., of Pitt Public Health; Zhen-Quiang Ma, M.D., M.P.H., M.S., of the Pennsylvania Department of Health; and Linda Robertson, Dr.P.H., M.S.N., R.N., of UPMC Hillman Cancer Center.

This research was supported by grants from the National Cancer Institute (T32CA186873) and the Arnold Palmer Endowment Fund.

To read this release online or share it, visit http://www.upmc.com/media/news/071019-maternal-obesity-childhood-cancer.

About the University of Pittsburgh Graduate School of Public Health

The University of Pittsburgh Graduate School of Public Health, founded in 1948 and now one of the top-ranked schools of public health in the United States, conducts research on public health and medical care that improves the lives of millions of people around the world. Pitt Public Health is a leader in devising new methods to prevent and treat cardiovascular diseases, HIV/AIDS, cancer and other important public health problems. For more information about Pitt Public Health, visit the school’s Web site at http://www.publichealth.pitt.edu.

About UPMC Hillman Cancer Center

UPMC Hillman Cancer Center, the region’s only National Cancer Institute-designated Comprehensive Cancer Center, is one of the largest integrated community cancer networks in the United States. Backed by the collective strength of UPMC and the University of Pittsburgh School of Medicine, UPMC Hillman Cancer Center has more than 60 locations throughout Pennsylvania and Ohio with cancer centers and partnerships internationally. Consistently ranked by U.S. News & World Report for excellence in cancer care, the more than 2,000 physicians, researchers and staff are leaders in molecular and cellular cancer biology, cancer immunology, cancer virology, biobehavioral oncology, and cancer epidemiology, prevention, and therapeutics. UPMC Hillman Cancer Center is transforming cancer research, care, and prevention — one patient at a time.

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