银杏叶可以帮助治疗2型糖尿病 Ginkgo biloba may aid in treating type 2 diabetes

CINCINNATI-根据辛辛那提大学医学院的研究人员共同撰写的一项研究,一种流行的膳食补充剂银杏叶提取物可能在对抗2型糖尿病方面具有一定的治疗效果。

“在糖尿病大鼠中,银杏叶对胰岛β细胞的胰岛素分泌有很好的作用,通过产生类似于我们在健康非糖尿病大鼠中看到的恢复作用,”Helal Fouad Hetta说,博士,消化疾病UC分部的博士后研究员和科学家。 Hetta还是埃及Assiut大学医学院医学微生物学和免疫学系的教师。

由13名研究人员组成的国际研究小组在动物模型中的研究发表在糖尿病,代谢综合征和肥胖:目标和治疗杂志上,可在线获取。该研究的第一作者是沙特阿拉伯Jazan大学的Ahmed Saleh博士。

“来自银杏的提取物经常被用于传统医学中,并且已被证明具有抗氧化能力,”Hetta说。据报道,“已经通过磁场的磁化水可降低血糖,改善糖尿病大鼠模型中的抗氧化状态和脂质谱。”

Hetta解释说,在这项研究中,2型糖尿病是通过给大鼠喂食高脂肪饮食8周,然后腹腔内注射单一低剂量的链脲佐菌素诱导的。将40只大鼠随机分为4组:非糖尿病对照组和3个糖尿病组。一个糖尿病组作为阳性对照(糖尿病),而另外两组分别口服给予银杏叶水提取物和磁化水四周。

糖尿病大鼠的β细胞减少,胰岛素分泌减少。在将银杏叶和磁化水添加到他们的饮食中后,胰腺β细胞的质量和这些细胞中的胰岛素量显着增加,几乎恢复到正常水平,特别是在银杏叶治疗组中,Hetta说。

此外,Hetta说,银杏叶和磁化水都可以通过下调胰腺组织中的两种抗氧化酶谷胱甘肽和超氧化物歧化酶2来改善抗氧化状态并减少与2型糖尿病相关的氧化应激。

Hetta说,这些针对银杏叶对2型糖尿病影响的研究结果是初步的。

“我们仍需要更多关于2型糖尿病可能获益的证据,因此正在进行研究,”Hetta说。 “我们的研究结果需要在大样本量的人体临床试验中进行测试。

“银杏是最古老的活树种之一,”Hetta说。 “大多数银杏产品都是用从叶子中提取的提取物制成的。大多数关于银杏的研究都集中在它对痴呆和年龄相关记忆障碍的影响,如阿尔茨海默病和由于血流量过少或跛行引起的疼痛。它通常以口服片剂,提取物,胶囊或茶的形式提供。低剂量使用时无毒,但可与其他药物相互作用。“

“我不建议吃生的或烤的银杏种子,因为它们可能有毒,”侯赛因说。 “如果使用它,应该作为胶囊或片剂服用。此外,如果您正在服用药物,请在考虑银杏之前咨询您的医生。“

该研究的合作者包括来自沙特阿拉伯Jazan大学的Mamdouh Anwar,Ahmed E. Zayed,Gamal Afifi,Emad Shaheen和Hassien Alnashiri。来自埃及Assiut大学的其他共同合作者包括Manal El Sayed Ezz Eldeen,Asmaa MS Gomaa,Mahmoud Abd-Elkareem,Alaa Sayed Abou-Elhamd,Ghada Mohamed和Ahmed M. Kotb。

这项工作由沙特阿拉伯Jazan大学科学研究院院长,Grant#37/7/200110资助。

该研究的作者报告说,这项工作没有利益冲突。

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NEWS RELEASE 

Ginkgo biloba may aid in treating type 2 diabetes

University of Cincinnati researcher finds promising results in rats

UNIVERSITY OF CINCINNATI

IMAGE
IMAGE: HELAL FOUAD HETTA, PHD, IS SHOWN IN THE UC COLLEGE OF MEDICINE. view more 

CREDIT: COLLEEN KELLEY/UNIVERSITY OF CINCINNATI

CINCINNATI–The extract of the leaves of Ginkgo biloba, a popular dietary supplement, may offer some therapeutic benefits in fighting Type 2 diabetes, according to a study co-authored by a researcher at the University of Cincinnati (UC) College of Medicine.

“In diabetic rats Ginkgo biloba had a very good effect on the beta cells of Langerhans–cells in the pancreas responsible for insulin secretion–by creating a restorative effect similar to what we see in healthy non-diabetic rats,” says Helal Fouad Hetta, PhD, a postdoctoral fellow and scientist in the UC Division of Digestive Diseases. Hetta is also on faculty at Egypt’s Assiut University College of Medicine in the Department of Medical Microbiology and Immunology.

The study in animal models by an international team of 13 researchers was published in the journal Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy and is available online. The first author on the research is Ahmed Saleh, PhD, Jazan University in Saudi Arabia.

“The extracts derived from Ginkgo biloba have been frequently used in traditional medicine and have been shown to exhibit antioxidant potency,” says Hetta. “Magnetized water, which has been passed through a magnetic field, has also been reported to reduce blood glucose, improve antioxidant status and lipid profiles in diabetic rat models.”

In this study, Type 2 Diabetes was induced by feeding rats a high-fat-diet for eight weeks followed by intra-peritoneal injection of a single low dose of streptozotocin, explains Hetta. Forty rats were randomly assigned to four groups: a non-diabetic control group and three diabetic groups. One diabetic group served as a positive control (diabetic), while the other two groups were orally administered with water extract of Ginkgo biloba leaves and magnetized water for four weeks, respectively.

The beta cells of diabetic rats are reduced and insulin secretion is curtailed. After having Ginkgo biloba and magnetized water added to their diets, the mass of the pancreatic beta cells and the amount of insulin in these cells was shown to increase markedly, almost back to normal levels, particularly in the Ginkgo biloba-treated group, says Hetta.

In addition, both Ginkgo biloba and magnetized water improved the anti-oxidant status and reduced the oxidative stress associated with type 2 diabetes by down regulation of the two antioxidant enzymes, glutathione and superoxide dismutase 2, in the pancreatic tissue, says Hetta.

These findings for Ginkgo biloba’s impact on Type 2 diabetes are preliminary, says Hetta.

“We still need more evidence about possible benefits for Type 2 diabetes so there is ongoing research,” says Hetta. “Our findings need to be tested in human clinical trials of large sample size.

“Gingko biloba is one of the oldest living tree species,” says Hetta. “Most Ginkgo products are made with extract prepared from leaves. Most research on Gingko focuses on its effects on dementia and age-related memory impairment such as Alzheimer’s disease and pain caused by too little blood flow or claudication. It is commonly available as an oral tablet, extract, capsule or tea. It is not toxic when used in low dosages, but can interact with other medicines.”

“I would not recommend eating raw or roasted Ginkgo seeds because they can be poisonous,” says Hussein. “It should be taken as a capsule or in tablets if used. Also, if you are currently taking medications please consult with your physicians before considering Ginkgo biloba.”

Collaborators on the study include Mamdouh Anwar, Ahmed E. Zayed, Gamal Afifi, Emad Shaheen, and Hassien Alnashiri, all from Jazan University in Saudi Arabia. Additional co-collaborators, all from Assiut University in Egypt include Manal El Sayed Ezz Eldeen, Asmaa MS Gomaa, Mahmoud Abd-Elkareem, Alaa Sayed Abou-Elhamd, Ghada Mohamed and Ahmed M. Kotb.

The work was funded by the Deanship of Scientific Research, Jazan University, Saudi Arabia, Grant # 37/7/00110.

The authors of the study report no conflicts of interest in this work.

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