间歇性禁食可以帮助预防2型糖尿病 Intermittent fasting protects mice from type 2 diabetes

评论:这可能意味着间歇性禁食可以帮助预防2型糖尿病。
根据德国人类营养研究所Potsdam-Rehbruecke的最新研究,每隔一天禁食大大降低了在吃富含脂肪的饮食的小鼠中发生2型糖尿病的可能性。本周在荷兰乌得勒支的摄入行为研究学会年会上提出的这些研究结果表明,定期禁食可以减少胰腺中的脂肪堆积,从而防止2型糖尿病的发作。 “我们观察到胰腺脂肪细胞直接影响胰岛胰岛素分泌,这可以通过饮食模式改变”,负责这项研究的博士后研究员Mandy Stadion博士说。

“众所周知,脂肪肝可促进2型糖尿病的发展,间歇性禁食通过减少小鼠和男性的肝脏脂肪来改善胰岛素敏感性,”德国人类研究所系实验性糖尿病学系主任AnnetteSchürmann教授解释道。该研究的营养和资深作者。 “然而,人们对肥胖期间胰腺中脂肪细胞的形成知之甚少,它们对胰岛细胞功能的详细影响以及间歇性禁食是否可以预防脂肪性胰腺。”

对于这些研究,研究人员提供了一组易患糖尿病的小鼠,可以无限制地获得高脂饮食。每隔一天对这些小鼠进行食物限制(间歇性禁食)。与对照条件相比,间歇性禁食导致胰腺脂肪显着减少 – 与糖尿病抵抗小鼠的水平相似 – 以及降低血糖水平和改善胰岛细胞功能。

Schürmann解释说:“我们认为,胰岛细胞的胰岛素分泌增加,尤其是糖尿病易感小鼠的胰岛素分泌增加,导致更快速的功能丧失,最终导致胰岛细胞死亡。”虽然这种功能丧失最终导致了2型糖尿病的发展,但研究人员对间歇性禁食可以防止导致胰岛素增加的脂肪积聚的发现持乐观态度,这可能揭示糖尿病治疗预防和治疗的新途径。

Comment:  This could mean that intermittent fasting can help prevent type 2 diabetes.
NEWS RELEASE 

Intermittent fasting protects mice from type 2 diabetes

SOCIETY FOR THE STUDY OF INGESTIVE BEHAVIOR

Every-other-day fasting substantially reduces the likelihood of developing type 2 diabetes in mice eating a fat-rich diet, according to new research out of the German Institute of Human Nutrition Potsdam-Rehbruecke. These findings, presented this week at the annual meeting of the Society for the Study of Ingestive Behavior in Utrecht, Netherlands, suggest that periodic fasting can reduce fat accumulation in the pancreas and, in turn, prevent the onset of type 2 diabetes. “We observed that pancreatic fat cells directly affect islet insulin secretion and that this can be altered by eating patterns” said Dr. Mandy Stadion, a post-doctoral research fellow who led this study.

“It is well known that a fatty liver promotes the development of type 2 diabetes and that intermittent fasting improves insulin sensitivity by reducing liver fat in mice and men,” explained Professor Annette Schürmann, head of the Department Experimental Diabetology at the German Institute of Human Nutrition and senior author of the study. “However, little is known about the formation of fat cells in the pancreas during obesity, their detailed impact on islet-cell function and whether intermittent fasting can prevent a fatty pancreas.”

For these studies the researchers provided one group of diabetes-prone mice with unlimited access to a high-fat diet. These mice were subjected to food restriction every other day (intermittent fasting). Compared to the control condition, intermittent fasting resulted in remarkably reduced pancreatic fat – similar to levels of diabetes-resistant mice – as well as in lower blood sugar levels and improved islet-cell function.

“We believe that the elevated insulin secretion of pancreatic islet cells, particularly from diabetes-prone mice, initiates a more rapid loss of function and finally islet cell-death,”explaned Schürmann. And while this loss of function ultimately contributes to the development of type 2 diabetes, the researchers are optimistic the finding that intermittent fasting can prevent the fat accumulation that leads to increased insulin may reveal a new path forward in the therapeutic prevention and treatment of diabetes.

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Research citation: Intermittent fasting reduces pancreatic fat and prevents type 2 diabetes in mice
Mandy Stadion, Charline Quiclet, Anneke Gässler, Christian Baumeier, Tim J. Schulz, Annette Schürmann
German Institute for Human Nutrition Potsdam-Rehbruecke, Potsdam, Germany; German Center for Diabetes Research (DZD) München-Neuherberg, Germany
Presented July 2019, Society for the Study of Ingestive Behavior, Utrecht, Netherlands

Contact:
Mandy Stadion, PhD
stadion@dife.de
+49 (0) 33200 88 2140

@Leibniz_DIfE

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