用于替代BPA的化学物质可能导致血压升高 Chemicals used to replace BPA may lead to increased blood pressure

News Release 30-Mar-2020

The Endocrine Society

WASHINGTON–Common bisphenol A (BPA) substitutes can affect the developing fetus and cause hypertension in later life, suggests a rodent study accepted for presentation at ENDO 2020, the Endocrine Society’s annual meeting. The research will be published in a special supplemental section of the Journal of the Endocrine Society.

Chemicals such as bisphenol A (BPA) are widely used in the synthesis of plastics and are found in numerous consumer products. Most humans are exposed to BPA on a daily basis. BPA disrupts the body’s endocrine system by mimicking the hormone estrogen. BPA exposure has been linked with high blood pressure.

Based on studies over the last few decades, the U.S. Food and Drug Administration in 2012 banned the use of this chemical in baby bottles and infant formula packaging. Manufacturers often replace BPA with other chemicals such as bisphenol S (BPS) and bisphenol F (BPF). These substitute chemicals are often found in products labeled “BPA free.”

“Cardiovascular diseases are the leading causes of mortality among men and women. With the new blood pressure guidelines from the American Heart Association, almost half of the United States population–45.6%–has hypertension,” said study co-author Maryam Hazim Al Mansi of the University of Georgia College of Veterinary Medicine. “There may be several reasons for this high prevalence of hypertension in our population, but the effect of contaminants is overlooked and understudied.”

In the new study, Al Mansi and colleagues exposed pregnant rats to low levels of saline, BPA, BPS or BPF and followed the development of their offspring. The offspring were implanted with devices to measure their blood pressure. The researchers measured blood pressure once a week for 11 weeks over a 24-hour period. They found systolic (the top number in a blood pressure reading) and diastolic blood pressure (the bottom number) were significantly increased in animals exposed to BPA, BPS and BPF compared with those exposed to saline.

“These results suggest that even low-dose exposure to these chemicals can affect blood pressure in the offspring later in life,” said co-author Puliyur S. MohanKumar, B.V.Sc., Ph.D., of the University of Georgia. “It is important to avoid these exposures during pregnancy.”

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The Endocrine Society canceled its annual meeting, ENDO 2020, amid concerns about COVID-19. Visit our online newsroom for more information on accepted abstracts, which will be published in a special supplemental section of the Journal of the Endocrine Society.

Endocrinologists are at the core of solving the most pressing health problems of our time, from diabetes and obesity to infertility, bone health, and hormone-related cancers. The Endocrine Society is the world’s oldest and largest organization of scientists devoted to hormone research and physicians who care for people with hormone-related conditions.

The Society has more than 18,000 members, including scientists, physicians, educators, nurses and students in 122 countries. To learn more about the Society and the field of endocrinology, visit our site at http://www.endocrine.org. Follow us on Twitter at @TheEndoSociety and @EndoMedia.

For more information on biphenol F, read some abstracts about biphenol F studies.

用于替代BPA的化学物质可能导致血压升高

一项啮齿类动物研究被接受在内分泌学会年会ENDO 2020上发表，该研究表明，常见的双酚A（BPA）替代品会影响发育中的胎儿并在以后的生活中引起高血压。这项研究将发表在《内分泌学会杂志》的特殊补充部分。

诸如双酚A（BPA）之类的化学物质广泛用于塑料的合成中，并在众多消费产品中被发现。大多数人每天都暴露于BPA。 BPA通过模仿激素雌激素来破坏人体的内分泌系统。 BPA暴露与高血压有关。

根据过去几十年的研究，美国食品药品监督管理局于2012年禁止在婴儿奶瓶和婴儿配方奶粉包装中使用这种化学物质。制造商经常用双酚S（BPS）和双酚F（BPF）等其他化学品代替BPA。这些替代化学品经常在标有“不含BPA”的产品中找到。

心血管疾病是男女死亡的主要原因。根据美国心脏协会的新血压指南，美国将近一半的人口（45.6％）患有高血压。”研究合著者，佐治亚大学兽医学院的Maryam Hazim Al Mansi说。 “在我们的人群中高血压如此普遍流行可能有几个原因，但是污染物的影响却被忽视和研究不足。”

在这项新研究中，Al Mansi及其同事将怀孕的老鼠暴露于低水平的盐水，BPA，BPS或BPF中，并跟踪其后代的发育。后代植入了测量血压的装置。研究人员在24小时内每周测量一次血压，持续11周。他们发现，与暴露于盐水的动物相比，暴露于BPA，BPS和BPF的动物的收缩压（血压读数的最高数字）和舒张压（最低数字）显着增加。

佐治亚大学B.V.Sc.博士Puliyur S. MohanKumar的合著者说：“这些结果表明，即使低剂量接触这些化学物质也会影响后代的血压。” “在怀孕期间避免这些暴露很重要。”