High doses of vitamin C, caloric restricted diet can shrink cancer tumor 高劑量的維生素C，熱量限制飲食可以縮小癌症腫瘤

Editor’s comment: Is this the best treatment? In our opinion, it is not. Although it may be better than conventional treatments such as radiation therapy and chemotherapy because vitamin C may be less toxic to healthy cells, the cell death triggered by free radicals can still come with some collateral side effects. It should be kept in mind that free radicals can not only kill cells, they can injure cells and cause mutation, which can be the basis for cancer recurrence and secondary cancer. When the cancer comes back, no matter you have treated your cancer with vitamin C or chemotherapy, the cancer tends to be more aggressive and drug resistant. The best therapy is one that will not cause mutation!!

07/21/2020 (Tuesday) – (jkzx.com) – Very high doses of vitamin C administered intravenously along with a caloric restricted diet can help treat an aggressive colorectal cancer, potentially other types of cancer as well, according to a new study.

Better yet, unlikely most cancer treatments, this novel treatment is likely non-toxic for healthy cells.

Dr. Linus Pauling who won two Nobel prizes suggested in the 1970s that high doses of intravenous vitamin C could be used to treat cancer, but the medical circle ridiculed his idea as quackery.

The truth is, high doses of IV vitamin C have proved to be effective at fighting cancers as an adjuvant therapy. A clinical trial reported in 2017 found that high doses of vitamin C make radiotherapy and chemotherapy more tolerable and patients with brain cancer may survive longer when they used high doses of vitamin C.

The current rodent study now suggests that a fast-mimicking diet can work in synergy with vitamin C to fight colorectal cancer without resorting to chemotherapy or radiation therapy.

The new study was published in Nature Communications and readers can read the whole report free of charge.

One keyword is high doses.

When vitamin C is used in small doses, it serves as an antioxidant which scavenges highly reactive free radicals in cells and protect cells from being injured.

But when it is used in high doses, particularly when administered intravenously, vitamin C works as an pro-oxidant. Pro-xidants promote peroxidation of liquids, generating free radicals which damage macro molecules like proteins, lipids, and DNA and causing cell deaths.

Some research suggests that cancer cells that carry KRAS mutations are more vulnerable than healthy cells to the damage induced by free radicals. About 25% of all cancers and about 40% of all colorectal cancers are KRAS mutant.

Another keyword is synergy.

When vitamin C is used together with chemotherapy, the anticancer effect against KRAS-mutated cancer cells is also enhanced. But in this case, the therapy damages BOTH healthy and cancerous cells.

Although high doses of vitamin C and a fast-mimicking diet both help fight cancer when used alone, their anticancer efficacy is boosted drastically when they are used together. The cancerous cells are particularly vulnerable to the toxicity induced by this combination treatment.

Another keyword is free iron.

Previous studies have found that high concentrations of free iron makes it more effective for the free radical hydrogen peroxide to damage DNA.

KRAS mutant cancer cells are able to protect themselves from being damaged by free radicals by removing the free iron.

A fast-mimicking diet can disable the protective measure and make cancer cells vulnerable to free radical damage, which is desired for the killing of cancer cells.

編者按：這是最好的治療方法嗎？ 我們認為不是。 儘管由於維生素C對健康細胞的毒性較小，它可能比常規治療（如放射療法和化學療法）更好，但由自由基觸發的細胞死亡仍可能帶來一些附帶副作用。 應當記住，自由基不僅可以殺死細胞，而且可以傷害細胞並引起突變，這可能是癌症復發和繼發性癌症的基礎。 當癌症復發時，無論您是否用維生素C或化學療法治療了癌症，該癌症都傾向於更具侵略性和耐藥性。 最好的療法是不會引起突變的療法！

2020年7月21日（星期二）–（jkzx.com）根據一項新研究，靜脈內施用高劑量的維生素C以及熱量有限的飲食可以幫助治療侵襲性大腸癌，也可能有助於治療其他類型的癌症。

更好的是, 不像大多數癌症治療方法，這種新穎的治療方法對健康細胞無毒。

曾獲得兩次諾貝爾獎的利納斯·鮑林（Linus Pauling）博士在1970年代提出，可以將大劑量的靜脈注射維生素C用於治療癌症，但醫學界對他的主意是嘲諷。

事實是，高劑量的IV維生素C已被證明是有效的抗癌手段。 2017年報導的一項臨床試驗發現，高劑量的維生素C使放射療法和化學療法更具耐受性，而腦癌患者使用高劑量的維生素C可能存活更長的時間。

目前的囓齒動物研究表明， 禁食飲食可以與維生素C協同作用來抵抗結腸直腸癌，而無需訴諸化學療法或放射療法。

這項新研究發表在《自然通訊》上，讀者可以免費閱讀整個報告。

一個關鍵詞是高劑量。

小劑量使用維生素C時，它可以作為抗氧化劑，清除細胞中高反應性的自由基，保護細胞免受傷害。

但是，當高劑量使用維生素C時，尤其是靜脈內給藥時，維生素C可以作為促氧化劑。助氧化劑促進液體的過氧化，產生自由基，這些自由基會破壞蛋白質，脂質和DNA等大分子，並導致細胞死亡。

一些研究表明，帶有KRAS突變的癌細胞比健康細胞更容易受到自由基的誘導。大約25％的癌症和大約40％的大腸癌是KRAS突變體。

另一個關鍵詞是協同作用。

當維生素C與化學療法一起使用時，對KRAS突變的癌細胞的抗癌作用也會增強。但是在這種情況下，這種療法會損害健康和癌細胞。

儘管單獨使用高劑量的維生素C和禁食飲食都可以幫助抵抗癌症，但將它們一起使用時，它們的抗癌功效會大大提高。癌細胞特別容易受到這種聯合治療誘導的毒性的影響。

另一個關鍵字是游離鐵。

先前的研究發現，高濃度的游離鐵使其對自由基過氧化氫破壞DNA更為有效。

KRAS突變型癌細胞能夠通過去除游離鐵來保護自身免受自由基的破壞。

禁食飲食可能會使保護措施無效，並使癌細胞容易受到自由基的破壞，這是殺死癌細胞所需要的。