Vitamin D may help prevent a common side effect of anti-cancer immunotherapy 维生素D可能有助于预防抗癌免疫疗法的常见副作用

中文版谷歌中文翻譯(90% 準確率) | English translation
Buy/Sell Your Domains Here。在這裡購買/出售您的域名
Contact Dr. Lu for information about cancer treatments。聯繫盧博士,獲取有關癌症治療資訊。

NEWS RELEASE 22-JUN-2020

Comment: Vitamin D in itself is an anticancer substance. The pharmaceutical companies know the anticancer effect. They cannot patent vitamin D so they chemically synthesize derivatives of this vitamin and patent them. The only concern is, when therapeutic doses of vitamin D can disturb the calcium metabolism in bones, according to reports. But you never know the truth. Vitamin D deficiency is linked to 17 forms of cancer.

評論:維生素D本身是一種抗癌物質。 製藥公司知道其抗癌作用。 他們無法獲得維生素D的專利,因此他們化學合成了這種維生素的衍生物並獲得了專利。 據報導,唯一需要關注的是,當治療劑量的維生素D會干擾骨骼中的鈣代謝。 但是你永遠不知道真相。 維生素D缺乏症與17種癌症有關。

WILEY

New research indicates that taking vitamin D supplements may help prevent a potentially serious side effect of a revolutionary form of anti-cancer therapy. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society (ACS).

Immune checkpoint inhibitors help the immune system recognize and combat cancer cells, and although these treatments have helped many patients and have prolonged lives, they can cause side effects such as colitis, an inflammatory reaction in the colon. “Immune checkpoint inhibitor-induced colitis can limit the use of such life-saving drugs leading to discontinuation of treatment. While it is one of the most common and severe adverse events of immunotherapy, there is a lack of understanding of the risk factors that could be modified to prevent colitis,” said Osama Rahma, MD, of the Dana-Farber Cancer Institute and Harvard Medical School, in Boston.

Dr. Rahma and his colleagues conducted a study that examined whether taking vitamin D supplements might reduce the risk of colitis in patients receiving immune checkpoint inhibitors to treat their cancer. The team chose this strategy because previous studies have found that vitamin D may affect the immune system in cases of autoimmune disorders and inflammatory bowel disease.

The study included information on 213 patients with melanoma who received immune checkpoint inhibitors between 2011 and 2017. Thirty-seven (17 percent) of these patients developed colitis. Sixty-six patients in the study (31 percent) took vitamin D supplements before starting treatment with immune checkpoint inhibitors.

Patients who took vitamin D had 65 percent lower odds of developing colitis, after adjustments for confounding factors. These findings were validated in another group of 169 patients, of whom 49 (29 percent) developed colitis. In this validation group, use of vitamin D was linked with 54 percent lower odds of developing colitis.

“Our findings of a link between vitamin D intake and reduced risk for colitis could potentially impact practice if validated in future prospective studies,” said Dr. Rahma. “Vitamin D supplementation should be tested further to determine if it could be a safe, easily accessible, and cost-effective approach towards preventing immunotherapy’s gastrointestinal toxicity and extending the effectiveness of immune checkpoint inhibitor treatment in cancer patients.”

###Additional Information

NOTE: The information contained in this release is protected by copyright. Please include journal attribution in all coverage. A free abstract of this article will be available via the Cancer News Room upon online publication. For more information or to obtain a PDF of any study, please contact:

Penny Smith +44 (0) 1243 770448 (UK)
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Full Citation: “Vitamin D Intake is Associated with Decreased Risk of Immune Checkpoint Inhibitor-Induced Colitis.” Shilpa Grover, Michael Dougan, Kevin Tyan, Anita Giobbie-Hurder, Steven M. Blum, Jeffrey Ishizuka, Taha Qazi, Rawad Elias, Kruti B. Vora, Alex B. Ruan, William Martin-Doyle, Michael Manos, Lauren Eastman, Meredith Davis, Maria Gargano, Rizwan Haq, Elizabeth I. Buchbinder, Ryan J. Sullivan, Patrick A. Ott, F. Stephen Hodi, and Osama E. Rahma. CANCER; Published Online: June 22, 2020 (DOI: 10.1002/cncr.32966).

URL Upon Publication: http://doi.wiley.com/10.1002/cncr.32966

Author Contact: Molly McHale, at Associate Director of Media Relations at the Dana-Farber Cancer Institute, at [email protected] or +1 617-632-5675.

About the Journal

CANCER is a peer-reviewed publication of the American Cancer Society integrating scientific information from worldwide sources for all oncologic specialties. The objective of CANCER is to provide an interdisciplinary forum for the exchange of information among oncologic disciplines concerned with the etiology, course, and treatment of human cancer. CANCER is published on behalf of the American Cancer Society by Wiley and can be accessed online.

Follow us on Twitter @JournalCancer

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