高血清维生素D水平降低乳腺癌死亡风险高达63％

Saturday March 3, 2019 (jkzx.com) — 2017年在JAMA Oncology上发表的一项研究表明暗示，服用高剂量的维生素D(vitamin D)不仅可以帮助预防乳腺癌(breast cancer)，还可以帮助治疗这种疾病。

之前的研究已将17种类型的癌症与维生素D缺乏联系起来，如果患者维持高血清维生素D，则可预防高达75％的乳腺癌病例。

目前的研究是在San Francisco Bay Area和加利福尼亚州中部山谷进行的。本文旨在了解维生素D如何影响乳腺癌患者的预后。

对于该研究，要求乳腺癌患者在基线后12, 24, 48, 72 和96个月以及在诊断2个月时测试血液维生素D水平。

研究人员发现晚期乳腺癌患者的血清维生素D（25OHD）水平较低。在绝经前三阴性乳腺癌女性中发现最低水平。

此外，研究人员发现血清维生素D水平与疾病进展和死亡的风险呈负相关。与最低三分位数相比，维生素D最高三分位数的乳腺癌患者更容易存活。

调整其他因素后，血清维生素D水平较高的女性与较低水平的女性相比，死亡的可能性降低28％。

在绝经前妇女中发现了维生素D与乳腺癌和侵袭性疾病的死亡风险之间最强的联系。高血清维生素D水平降低死亡风险高达63％。(DR. LU)

Vitamin D helps breast cancer patients

A study published in 2017 in JAMA Oncology indicates that taking high doses of vitamin D can not only help prevent breast cancer, but also help treat the disease.

Previous studies have linked 17 types of cancers to Vitamin D deficiency and 75% cases of breast cancer could be prevented if patients maintain high serum vitamin D.

The current study was conducted in San Francisco Bay Area and central Valley, California. It was intended to see how vitamin D influences the prognosis of breast cancer patients.

For the study, breast cancer patients were asked to allow a test for blood vitamin D levels with 2 months of diagnosis, 12, 24, 48, 72 and 96 months after baseline.

Researchers found the lower serum vitamin D (25OHD) levels in women with advanced stage breast cancer.  The lowest level was found in postmenopausal women with triple-negative breast cancer.

In addition, serum vitamin D levels were inversely associated with the risk of disease progression and death.  Compared to the lowest tertile, breast cancer patients in the highest tertile of vitamin D were much more likely to survive.

After adjustment for other factors, the women with high levels of serum vitamin D were found 28% less likely to die, compared to those with lower levels.

The strongest association between vitamin D and death risk from breast cancer and invasive disease was found among postmenopausal women. The risk reduction was up to 63%.