Estrogen plus progestin and lung cancer | 雌激素加孕激素和肺癌

中文版谷歌中文翻譯(90% 準確率) | English translation
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Estrogen plus progestin and lung cancer

Previous studies of data from the Women’s Health Initiative study have shown that hormone replacement therapy can increase the risk of breast cancer and heart disease. New research based on the same set of data now suggests that hormone replacement therapy may also increase the risk of lung cancer death in female hormone users.

For the study, scientists at the Los Angeles Biomedical Research Institute at UCLA Medical Center in Los Angeles and other organizations analyzed data from 16,608 postmenopausal women aged 50 to 79. Subjects were randomized to receive 0.625 mg conjugated equine estrogen plus 2.5 mg medroxyprogesterone acetate or placebo. They were followed for a total of 14 years.

The study found that women who used hormones were 12 percent more likely to develop lung cancer. And these women were more likely to die from lung cancer, but the difference between the study and control groups was not significant.

The study showed that the women’s risk of death was attenuated during the 14-year follow-up period compared with the risk over a 4.5-year period of hormone therapy. Early research showed that women who received hormone therapy had a 71 percent higher risk of dying from lung cancer than those who did not receive it during the first 8 years of follow-up.

The study concluded that the risk of death from lung cancer was high but decreased over time. The chronic effect of hormone replacement therapy on the risk of death from lung cancer almost disappeared 14 years after the intervention, while the risk of developing cancer was 12% higher than in the control group.

A combination of estrogen and progestin is used in the West to relieve postmenopausal symptoms in women.








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