Beetroot juice increases effectiveness of breast cancer drug | 甜菜根汁增加对乳腺癌药物的疗效

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Beetroot juice increases effectiveness of breast cancer drug

 

Drinking beetroot juice not only helps reduce the irreversible cardiotoxicity of the chemotherapy drug doxorubicin on healthy cells, but also increases the efficacy of the drug in vitro on breast cancer cells, a new study shows.

Previous studies have shown that high in nitrates and antioxidants, beet juice can help prevent the development of cancer (or act as a chemo-preventive agent).

In this study, adult rat cardiomyocytes and MDA-MB-231 breast cancer cells were treated with beetroot juice at doses of 0.5, 5, 50, 250 and 500 μg per ml. Some cells were also treated with doxorubicin.

Decreased death in cardiomyocytes but increased in breast cancer cells after co-treatment with beetroot juice and doxorubicin for 24 hours.

Adjuvant therapy reduces the production of reactive oxygen species (ROS) in healthy cardiomyocytes and increases ROS in breast cancer cells.

Adjuvant therapy also significantly reduced cell viability in breast cancer cells. Beetroot juice increases doxorubicin-induced apoptosis in breast cancer cells.

The study concluded: “Low concentrations of BRJ (beet juice) with DOX (doxorubicin) represent the most effective combination of cardio- and chemoprevention.”

“These findings provide insight into the possible cardioprotective capabilities of the BRJ in cancer patients treated with anthracycline chemotherapy.”

Early research also suggests that beetroot juice may also help protect against pancreatic and prostate cancer.

Together, previous studies have shown that beetroot and carrot juice can help fight chronic lymphocytic leukemia.

 

 

一项新的研究表明,饮用甜菜根汁,不仅可以帮助减少对健康细胞的化疗药物阿霉素的不可逆转的心脏毒性,还会增加对乳腺癌细胞的体外药物的疗效。

早先的研究已经表明高量的硝酸盐和抗氧化剂,甜菜车汁可以帮助预防癌症的发展(或用作化学 – 预防剂)。

在这项研究中,成年大鼠心肌细胞和MDA-MB-231乳腺癌细胞用在剂量为0.5,5,50,250和每毫升500微克甜菜根汁进行处理。一些细胞也与阿霉素治疗。

在心肌细胞死亡减少,但用甜菜根汁和阿霉素共处理24小时后在乳腺癌细胞中增加。

助治疗减少活性氧(ROS)的健康心肌细胞的产生和在乳腺癌细胞中增加的ROS。

助治疗也显著减少在乳腺癌细胞的细胞生存力。甜菜根汁增加乳腺癌细胞中阿霉素诱导的凋亡。

这项研究总结说:“低浓度的BRJ(甜菜汁)与DOX(阿霉素)表示心脏和化学预防的最有效的组合。”

“这些发现提供了洞察与蒽环类化疗药物治疗的癌症患者BRJ的可能心脏保护的能力。”

早期的研究也表明,甜菜根汁也有助于防止胰腺癌和前列腺癌。

以前的研究还在一起表明,甜菜根汁和胡萝卜汁可以帮助对抗慢性淋巴细胞白血病。


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