Contact Dr. Lu for information about cancer treatments。聯繫盧博士,獲取有關癌症治療資訊。
Frequent consumption of peanuts by cancer patients may increase risk of cancer spread 吃太多花生可能會增加癌症擴散的風險
Contact Dr. Lu for information about cancer treatments。聯繫盧博士,獲取有關癌症治療資訊。
Frequent consumption of peanuts by cancer patients may increase risk of cancer spread
A study by University of Liverpool researchers has identified new factors accompanying previous findings that frequent consumption of peanuts by cancer patients could increase risk of cancer spread.
The study, published in Carcinogenesis shows that Peanut agglutinin (PNA) – a carbohydrate-binding protein that rapidly enters into the blood circulation after peanuts are eaten – interacts with blood vascular wall (endothelial) cells to produce molecules called cytokines.
The cytokines in question, IL-6 and MCP-1 are well-known promoters of cancer metastasis. The increased cytokine production causes other endothelial cells to express more cell surface adhesion molecules, making them more attractive to the circulating tumour cells and thus potentially promoting metastasis.
In an earlier study, Corresponding Author Professor Lu-Gang Yu and colleagues reported that circulating PNA binds to a special sugar chain, which occurs mainly on pre-cancerous and cancer cells, and interacts with a larger protein expressed on the surface of tumour cells in the bloodstream.
This interaction triggers changes in the larger protein, resulting in underlying adhesion molecules on the surface of the cancer cell to become exposed, making the cancer cells stickier and easier to attach themselves to the blood vessels. It also allows the cancer cells to form small clumps that prolong the survival of cancer cells in the body’s circulation. Many epithelial cancers spread to the other organs through traveling through the bloodstream.
Professor Lugang Yu said: “Although further research and investigation are still needed, these studies suggest that very frequent consumption of peanuts by cancer patients might increase the risk of metastatic spread.
“Reassuringly though, a large US study reported no significant impact of peanut consumption on cancer mortality. In another study, peanut consumption was reported to have no significant effect on prognosis in men with established prostate cancer. In our previous healthy volunteer study, substantial blood concentrations of PNA were only seen transiently one hour or so after consumption of a large dose (250g) of peanuts, so it may be that ‘normal’ peanut consumption yielding lower PNA concentrations is harmless.
“Nevertheless, the possibility remains that circulating PNA, at least at the relatively high levels found shortly after a large “dose” of peanuts, could have a significant biological effect on tumour cells circulating at that time, with a potential for increased risk of metastasis. Heavy or very frequent peanut consumption therefore might be better avoided by cancer patients.”
The possible impact of heavy peanut consumption by cancer patients on survival will need to be investigated in further population-based epidemiological studies.
This study was supported by the American Institute for Cancer Research.
The study Appearance of peanut agglutinin in the blood circulation after peanut ingestion promotes endothelial secretion of metastasis-promoting cytokines is available here: https://academic.oup.com/carcin/advance-article-abstract/doi/10.1093/carcin/bgab059/6315265?redirectedFrom=fulltext
Journal
Carcinogenesis
DOI
https://doi.org/10.1093/carcin/bgab059
Subject of Research
Cells
Article Title
Appearance of peanut agglutinin in the blood circulation after peanut ingestion promotes endothelial secretion of metastasis-promoting cytokines
Article Publication Date
4-Jul-2021
利物浦大學研究人員的一項研究確定了新因素,這些因素與先前的研究結果相一致,即癌症患者經常食用花生會增加癌症擴散的風險。
發表在 Carcinogenesis 上的這項研究表明,花生凝集素 (PNA)——一種碳水化合物結合蛋白,在食用花生後會迅速進入血液循環——與血管壁(內皮)細胞相互作用,產生稱為細胞因子的分子。
所討論的細胞因子 IL-6 和 MCP-1 是眾所周知的癌症轉移促進劑。細胞因子產生的增加導致其他內皮細胞表達更多的細胞表面粘附分子,使它們對循環腫瘤細胞更具吸引力,從而可能促進轉移。
在較早的一項研究中,通訊作者 Lu-Gang Yu 教授及其同事報告說,循環中的 PNA 與一種特殊的糖鏈結合,該糖鍊主要存在於癌前細胞和癌細胞上,並與在腫瘤細胞表面表達的較大蛋白質相互作用。血液。
這種相互作用觸發了較大蛋白質的變化,導致癌細胞表面的潛在粘附分子暴露出來,使癌細胞更粘,更容易將自己附著在血管上。它還允許癌細胞形成小團塊,從而延長癌細胞在身體循環中的存活時間。許多上皮癌通過血液傳播到其他器官。
Lugang Yu教授說:“雖然還需要進一步的研究和調查,但這些研究表明,癌症患者非常頻繁地食用花生可能會增加轉移擴散的風險。
“令人欣慰的是,美國的一項大型研究報告稱,食用花生對癌症死亡率沒有顯著影響。在另一項研究中,據報導食用花生對患有前列腺癌的男性的預後沒有顯著影響。在我們之前的健康志願者研究中,僅在食用大劑量(250 克)花生後一小時左右才短暫地觀察到大量的 PNA 血液濃度,因此“正常”花生食用產生較低的 PNA 濃度可能是無害的。
“儘管如此,循環 PNA 的可能性仍然存在,至少在大量“劑量”花生後不久發現的相對較高的水平,可能對當時循環的腫瘤細胞產生顯著的生物學影響,並有可能增加轉移的風險.因此,癌症患者最好避免食用大量或非常頻繁的花生。”
需要在進一步的基於人群的流行病學研究中調查癌症患者大量食用花生對生存的可能影響。
這項研究得到了美國癌症研究所的支持。