Garlic compound ajoene helps fight acute myeloid leukaemia 大蒜複合物阿霍烯有助於對抗急性髓細胞性白血病

有健康問題,聯繫陸博士

Monday 04/05/2021 (jkzx.com) — Ajoene, a compound from Garlic (Allium Sativum) may be used to treat acute myeloid leukaemia (AML) because of its anti-leukemia activity, according to an editorial published in the journal Leukemia Research in 2004.

H.T. Hassan from University of Lincoln, author of the editorial says that the anti-tumor activity of garlic has been known for more than 3000 years.

Some sulfur compounds other than ajoene identified in garlic are already known for its effectiveness at inhibiting the proliferation and inducing apoptosis of several cancers such as breast cancer, bladder cancer, colorectal cancer, hepatic cancer, prostate cancer, lymphoma, and skin cancer.

The new compound known as ajoene (4,5,9-trithiadodeca-1,6,11-triene-9-oxide) can be produced efficiently from another sulfur compound isolated from garlic – allicin. It is only that ajoene is more stable than its precursor allicin which is desired.

Early studies show that ajoene can help thrombosis, bacterial infections, high cholesterol and skin cancer in patients. Ajoene
has been found to be able to inhibit proliferation and induce apoptosis of several human leukemia cell lines. And most recently it was found that ajoene could induce 30% apoptosis in myeloblasts from a patient with chronic myeloid leukemia.

Most recently researchers have found that ajoene can help boost the apoptosis of acute myeloid leukaemia induced by chemotherapy. Chemotherapy tends to cause some drug resistance in AML patients. Tests conducted with drug resistant AML cell cultures indicate that ajoene can enhance the apoptosis induced by chemotherapy in the treatment of refractory and/or relapsed AML patients and also elderly patients.

Garlic should be the number one anticancer food for every cancer patient. A patient who survived from brain cancer for 19 years considered garlic the most potent anti-cancer food.

H.T. Hassan (2004) Ajoene (natural garlic compound): a new anti-leukaemia agent for AML therapy, Leukemia Research, Volume 28, Issue 7, July 2004, Pages 667-671
https://doi.org/10.1016/j.leukres.2003.10.008

根據2004年發表在《白血病研究》雜誌上的社論,由於大蒜具有抗白血病活性,Ajoene是大蒜中的一種化合物,可用於治療急性髓樣白血病(AML)。

H T。林肯大學的哈桑(社論文章的作者)說,大蒜的抗腫瘤活性已經有3000多年的歷史了。

大蒜中鑑定出的除阿霍烯以外的一些硫化合物因其抑制多種癌症(例如乳腺癌,膀胱癌,結腸直腸癌,肝癌,前列腺癌,淋巴瘤和皮膚癌)的增殖並誘導其凋亡的作用而聞名。

可以從另一種從大蒜中分離出來的硫化合物-大蒜素,高效地生產出稱為阿霍烯的新化合物(4,5,9-三硫代十二烷基-1,6,11-三烯-9-氧化物)。只是阿霍烯比其所需的前體大蒜素更穩定。

早期研究表明,阿霍烯可以幫助患者血栓形成,細菌感染,高膽固醇和皮膚癌。阿約涅 已發現其能夠抑制幾種人白血病細胞系的增殖並誘導其凋亡。最近發現,阿霍烯能誘導患有慢性粒細胞白血病的患者的成纖維細胞中30%的細胞凋亡。

最近的研究人員發現,阿霍烯可以幫助促進化學療法誘導的急性髓性白血病的細胞凋亡。化學療法傾向於在AML患者中引起某些耐藥性。用耐藥性AML細胞培養物進行的測試表明,阿霍烯可以增強化學療法誘導的凋亡,從而治療難治性和/或複發性AML患者以及老年患者。

大蒜應成為每位癌症患者的第一大抗癌食品。一名從腦癌中存活了19年的患者認為大蒜是最有效的抗癌食品。

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