Ketone supplements may help curb cancer growth | 酮类补充剂可能有助于抑制癌症生长

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Ketone supplements may help curb cancer growth

A new study suggests that taking ketone supplements may help curb cancer growth and prolong survival in cancer patients.

Cancer cells follow a metabolic pathway that differs from normal metabolic pathways. In cancer cells, mitochondria generate energy by metabolizing glucose into lactate. Cancer cells do not use ketones for energy.

A high-fat, low-carb ketogenic diet has been tested as a cancer treatment. The authors of the current study tested ketone supplements and found that they could lead to a favorable condition called ketosis, as did a high-fat, low-carb keto biodiet.

In previous studies, the authors found that ketone supplementation inhibited the proliferation and survival of cancer cells in vitro and slowed tumor growth and prolonged survival in animals with metastatic cancer.

In the current study, the authors fed a line of healthy rats a ketone supplement for one to four months with uncontrolled glucose intake and found that the supplement increased blood ketone levels to therapeutic levels and reduced glucose levels by 20%.

Ketone supplementation investigates a number of metabolic parameters, suggesting that supplementation regimens protect against cancer. Parameters altered included oxidized glutathione and antioxidant capacity (carnosine and serine).

Carnosine was found four times higher in ketone-supplemented rats known to inhibit anaerobic glycolysis (a low energy production pathway), slow tumor growth and metastasis and prolong survival in cancer models.

Ketone supplementation also lowered some lysophospholipids, which are found higher in the blood of cancer patients and can induce tumorigenesis and metastasis in animals.

Also reduced were a number of pro-inflammatory biomarkers, including L-1β, IL-6, IFN-γ, MCP-1, and RANTES.

The study was short-term and no clear signs of serious effects were observed. This suggests that ketone supplementation appears to be safe and may be used as an adjunct therapy in the treatment of cancer.

The keto diet is thought to be useful in treating brain cancer because brain cells can only use glucose. But studies so far have not provided firm conclusions about the effects of such diets on brain tumors, even though in theory a ketogenic diet and ketone supplements could help treat cancer. (David Liu) (This report was originally published on foodconsumer.org)

 

酮类补充剂可能有助于抑制癌症生长

 

一项新的研究表明,服用酮类补充剂可能有助于抑制癌症生长和延长癌症患者的生存。

癌细胞遵循与正常代谢途径不同的代谢途径。在癌细胞中,线粒体通过将葡萄糖代谢成乳酸而产生能量。癌细胞不使用酮作为能量。

高脂低碳生酮饮食已被测试为癌症治疗。目前的研究的作者测试酮补充剂,发现他们可以导致一个有利的条件,称为酮症,正如高脂肪低碳酮生物饮食。

在以前的研究中,作者发现酮补充剂抑制体外癌细胞的增殖和存活并且减慢肿瘤生长并延长患有转移性癌症的动物的存活。

在目前的研究中,作者喂养健康大鼠一行酮补充剂一至四个月,葡萄糖摄入失控,发现这种补充增加血液中酮的水平到治疗水平,并且葡萄糖水平降低20%。

酮补充剂调查了许多代谢参数,表明补充方案可以防止癌症。改变的参数包括氧化型谷胱甘肽和抗氧化能力(肌肽和丝氨酸)。

肌肽在补充酮的大鼠中发现四倍高已知抑制无氧糖酵解(低能量产生途径),减慢肿瘤生长和转移并延长癌症模型中的存活。

酮补充剂还降低了一些溶血磷脂,其在癌症患者的血液中发现较高,可以在动物中诱导肿瘤发生和转移。

减少的还有许多促炎生物标志物,包括L-1β,IL-6,IFN-γ,MCP-1和RANTES。

这项研究是短期的,没有观察到严重影响的明显迹象。这表明酮补充剂似乎是安全的,并且可以用作治疗癌症的辅助疗法。

酮素饮食被认为可用于治疗脑癌,因为脑细胞只能使用葡萄糖。但是迄今为止的研究还没有提供关于这样的饮食对脑肿瘤的治疗效果的坚实结论,即使在理论上,生酮饮食和酮补充剂可以帮助治疗癌症。 (David Liu)(This report was originally published on foodconsumer.org)

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