定时释放的姜黄可以阻止癌细胞的生长 Timed release of turmeric stops cancer cell growth

中文版谷歌中文翻譯(90% 準確率) | English translation
Buy/Sell Your Domains Here。在這裡購買/出售您的域名
Contact Dr. Lu for information about cancer treatments。聯繫盧博士,獲取有關癌症治療資訊。


这项工作可以为骨肉瘤患者提供更好的术后治疗,骨肉瘤是儿童癌症死亡的第二大流行原因。研究人员,包括机械和材料工程学院的Susmita Bose,Herman和Brita Lindholm Endowed讲座教授以及研究生Naboneeta Sarkar,在ACS应用材料和接口杂志上报道了他们的工作。



“我希望人们知道这些天然化合物的有益作用,”Bose说。 “源自这些基于植物的产品的天然生物分子价格低廉,是合成药物的更安全的替代品。”




“这项研究引入了一个新的整合时代 – 现代3D打印技术与安全有效地使用替代医学相结合,可为骨组织工程提供更好的工具,”Bose说

News Release 

Timed release of turmeric stops cancer cell growth

Washington State University

PULLMAN, Wash. – A Washington State University research team has developed a drug delivery system using curcumin, the main ingredient in the spice turmeric, that successfully inhibits bone cancer cells while promoting growth of healthy bone cells.

The work could lead to better post-operative treatments for people with osteosarcoma, the second most prevalent cause of cancer death in children.

The researchers, including Susmita Bose, Herman and Brita Lindholm Endowed Chair Professor in the School of Mechanical and Materials Engineering, and graduate student Naboneeta Sarkar, report on their work in the journal, ACS Applied Materials and Interfaces.

Young patients with bone cancer are often treated with high doses of chemotherapy before and after surgery, many of which have harmful side effects. Researchers would like to develop gentler treatment options, especially after surgery when patients are trying to recover from bone damage at the same time that they are taking harsh drugs to suppress tumor growth.

Turmeric has been used in cooking and as medicine for centuries in Asian countries, and its active ingredient, curcumin has been shown to have anti-oxidant, anti-inflammatory and bone-building capabilities. It has also been shown to prevent various forms of cancers.

“I want people to know the beneficial effects of these natural compounds,” said Bose. “Natural biomolecules derived from these plant-based products are inexpensive and a safer alternative to synthetic drugs.”

However, when taken orally as medicine, the compound can’t be absorbed well in the body. It is metabolized and eliminated too quickly.

In their study, the researchers used 3D printing to build support scaffolds out of calcium phosphate. While most implants are currently made of metal, such ceramic scaffolds, which are more like real bone, could someday be used as a graft material after bone cancer surgery. The researchers incorporated curcumin, encapsulated in a vesicle of fat molecules into the scaffolds, allowing for the gradual release of the chemical.

The researchers found that their system inhibited the growth of osteosarcoma cells by 96 percent after 11 days as compared to untreated samples. The system also promoted healthy bone cell growth.

“This study introduces a new era of integration – where modern 3d printing technology is coupled with the safe and effective use of alternative medicine, which may provide a better tool for bone tissue engineering,” said Bose.


The researchers are continuing the unique area of research, studying the benefits of integrating other natural compounds in biomedical technology. The work was funded by the National Institutes of Health.

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