White button mushrooms could slow progression of prostate cancer 白蘑菇可能减慢前列腺癌的进展

有问题,联系陆博士

News Release 20-Mar-2021

Editor’s note: Prior studies indicates certain types of mushroom, white button mushroom not included, can help treat cancer. This study shows that white button mushroom can help at least prostate cancer. Its anticancer mechanism may not be the same. White button mushroom seems to suppress androgen receptor activity while other mushrooms such as shiitake and reishi boosts anticancer immunity.

编者注:先前的研究表明,某些类型的蘑菇(不含白纽扣蘑菇)可以帮助治疗癌症。 这项研究表明,白蘑菇可以帮助至少前列腺癌。 其抗癌机制可能不同。 白蘑菇似乎抑制了雄激素受体的活性,而其他蘑菇如香菇和灵芝则增强了抗癌免疫力。

More reports on mushrooms vs. prostate cancer.

吃蘑菇有助于预防前列腺癌 Eating mushrooms may help lower prostate cancer risk

Eating mushroom reduces prostate cancer risk in older men 食用蘑菇可降低老年男性患前列腺癌的風險

Mouse study suggests mushrooms may suppress androgen receptor activity

The Endocrine Society

Research News

WASHINGTON–The chemicals present in white button mushrooms may slow the progression of prostate cancer, according to a mouse study presented virtually at ENDO 2021, the Endocrine Society’s annual meeting.

“Androgens, a type of male sex hormone, promote the growth of prostate cancer cells by binding to and activating the androgen receptor, a protein that is expressed in prostate cells,” said lead researcher Xiaoqiang Wang, M.D., Ph.D., M.B. (A.S.C.P.), of the Beckman Research Institute of City of Hope, a comprehensive cancer center in Duarte, Calif. “White button mushrooms appear to suppress the activity of the androgen receptor.”

City of Hope’s Shiuan Chen, Ph.D., the principal investigator of this project, previously conducted a phase one clinical trial of white button mushroom powder in patients with recurrent prostate cancer, which indicated that the mushrooms reduced levels of prostate-specific antigen (PSA) in the blood, with minimal side effects. Heightened blood levels of PSA in men may indicate the existence of prostate tumors.

The new study aimed to understand the mechanism behind this finding. The researchers studied the mushroom extract’s effect on prostate cancer cells that were sensitive to androgen. They also studied the extract’s effect on mice implanted with human prostate tumors, which creates an animal model whose results would be more reliable as the research is translated to human clinical trials.

The researchers found that in prostate cancer cells, white button mushroom extract suppressed androgen receptor activity. They also found that in mice treated with white button mushroom extract for six days, prostate tumor growth was significantly suppressed, and levels of PSA decreased.

“We found that white button mushrooms contain chemicals that can block the activity of the androgen receptor in mouse models, indicating this fungus can reduce PSA levels,” Wang said. “While more research is needed, it’s possible that white button mushrooms could one day contribute to the prevention and treatment of prostate cancer.”

###

Endocrinologists are at the core of solving the most pressing health problems of our time, from diabetes and obesity to infertility, bone health, and hormone-related cancers. The Endocrine Society is the world’s oldest and largest organization of scientists devoted to hormone research and physicians who care for people with hormone-related conditions.

The Society has more than 18,000 members, including scientists, physicians, educators, nurses and students in 122 countries. To learn more about the Society and the field of endocrinology, visit our site at http://www.endocrine.org. Follow us on Twitter at @TheEndoSociety and @EndoMedia.

$$$ 如果你愿意,你可以在这捐款支持我们。谢谢。$$$
$$$ If you would, you can make a donation here to support us. Thank you. $$$