中文版谷歌中文翻譯（90% 準確率) | English translation
Buy/Sell Your Domains Here。在這裡購買/出售您的域名
Contact Dr. Lu for information about cancer treatments。聯繫盧博士，獲取有關癌症治療資訊。
High fructose diet can worsen the severity of covid 19 in men | 高果糖飲食會加重男性 COVID 19 的嚴重程度
Contact Dr. Lu for information about cancer treatments。聯繫盧博士，獲取有關癌症治療資訊。
. 2016 Apr 27;17(2):1470320316642915.
doi: 10.1177/1470320316642915. Print Apr-Jun 2016.
Fructose-rich diet induces gender-specific changes in expression of the renin-angiotensin system in rat heart and upregulates the ACE/AT1R axis in the male rat aorta
Affiliations
- PMID: 27121972
- PMCID: PMC5843877
- DOI: 10.1177/1470320316642915
Free PMC article
Abstract
Introduction: The cardiovascular renin-angiotensin system (RAS) could be affected by gender and dietary regime. We hypothesized that male rats will be more susceptible to activation of RAS in the heart and aorta, as a response to a fructose-rich diet (FRD).
Materials and methods: Both male and female Wistar rats were given a 10% (w/v) fructose solution for 9 weeks. We measured the biochemical parameters, blood pressure (BP) and heart rate. We used Western blot and real-time polymerase chain reaction (PCR) to quantify protein and gene expression.
Results: In the male rats, the FRD elevated BP and expression of cardiac angiotensin-converting enzyme (ACE), while the expression of angiotensin-converting enzyme 2 (ACE2) and angiotensin II Type 2 receptor (AT2R) were significantly decreased. In female rats, there were no changes in cardiac RAS expression due to FRD. Furthermore, the ACE/AT1R axis was overexpressed in the FRD male rats’ aortae, while only AT1R was upregulated in the FRD female rats’ aortae. ACE2 expression remained unchanged in the aortae of both genders receiving the FRD.
Conclusions: The FRD induced gender-specific changes in the expression of the RAS in the heart and aortae of male rats. Further investigations are required in order to get a comprehensive understanding of the underlying mechanisms of gender-specific fructose-induced cardiovascular pathologies.
Keywords: Angiotensin-converting enzyme; angiotensin receptor; aorta; diet; fructose; gender differences; heart; protein expression; rat; renin–angiotensin system.
© The Author(s) 2016.
Conflict of interest statement
Declaration of conflicting interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
刘 大卫
Trust God, not sinful people. Worship God, but not things/people. Let God lead you, but not let others lead you. 相信上帝，而不是有罪的人。 敬拜神，而不是事/人。 讓上帝帶領你，但不要讓別人帶領你。
