April 11, 2019 (jkzx.com) — 我们经常听到有人在说你不能饿死癌细胞。当然，这个词来自那些不知道他们在说什么的人。他们通常是医生因为他们需要你相信只有他们的西医才能治你的癌症。发表在“科学信号”杂志上的一项新研究证明他们说的是错误的。减少糖摄入量实际上可以杀死一些癌症。
We hear often that you cannot starve cancer cells to death. Of course, the word comes from those who do not know what they are talking about. A new study published in the journal Science Signaling proves that they are wrong. Reducing sugar intake can actually kill some cancers.
The report of the study explains why cutting back on sugar intake causes cancer cells to die. The researchers discover a new pathway that deprives cancer cells from access to sugar and cause cancer cells to die.
When cancer cells have a limited amount of sugar, they switch to a survival mode instead of the growth mode. And with a very limited amount of sugar available, they take in a great deal of calcium, which eventually kills the cancer cells.
For the study, the researchers used two cancer cell cultures. One culture got an extra amount of glucose, while the other did not. Both cultures were treated with a drug STF-31 that prohibits glucose transport into cancer cells and another drug thapsigargin that increased the level of cellular calcium.
As a result, the cancer cells with extra glucose were not affected while those without extra glucose were killed off. And better yet, this treatment does not have any side effects on the healthy cells.
But the researchers say that this approach does not work for all types of cancers. Only those that are sensitive to the glucose deprivation may get killed.
The study was conducted by researchers from Duke-NUS Medical School, the National University of Singapore, the Duke University School of Medicine, and the Medical University of Vienna. (Dr. Lu)