大蒜在解毒重金属如铅时,与普通螯合药物d-青霉胺一样有效

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Credit: Wikipedia

Credit: Wikipedia

Sunday March 3, 2019 (JKZX.com) — 发表在“基础与临床药理学和毒理学”杂志上的一项研究发现,大蒜(garlic)在解毒重金属如铅时,与普通螯合药物d-青霉胺(d-penicillamine)一样有效。而且大蒜引起的毒副作用几乎为零,而药物治疗可带来众多的副作用。

题为“大蒜和d-青霉胺治疗慢性职业性铅中毒(lead poisoning)的疗效比较”的研究旨在证实以前的动物研究已经证明大蒜(大蒜)可以有效地减少血液和组织中的铅。

在这项研究中,一个汽车电池工厂的117名工人参加了这项研究,他们分为两组,一组分别服用1000毫克大蒜提取物和1.2毫克大蒜素),每天三次,另一组服用每天服用250毫克青霉胺,也是每日三次。治疗持续了四周。

通过大蒜治疗,患者在烦躁,头痛和减少深腱反射和平均收缩压方面经历了显着的临床改善。用去甲基胺处理的组中未发现这些改善。

用大蒜处理,血铅浓度从426降低到347微克/升,而用d-青霉胺,铅浓度从417降低到315微克/升。差异不大。

用d-青霉胺治疗组比用大蒜治疗组更常出现副作用。

该研究的结论是,大蒜可以被推荐用于治疗轻度至中度的铅中毒。

在全球范围内,铅中毒导致0.2%的所有死亡和0.6%的残疾。暴露于铅等有毒重金属会危害人体的心血管,骨骼,胃肠,肾脏,生殖和神经系统。

婴儿,儿童和发展中神经系统的人比成人更容易发生铅中毒。 2008年发表在“公共科学图书馆”上的一项研究发现,当人们在童年时期接触过铅时,在成年后,他们的大脑比较小。

d-青霉胺是常用的,但它可引起一系列副作用,包括乳房增大,骨髓抑制,厌食,胶原蛋白紊乱,腹泻,味觉障碍,造成对肾脏,肝脏和肌肉的损害。

d-青霉胺治疗毒性很大,30%-60%的用d-青霉胺治疗的患者会出现副作用。相比之下,在按规定的剂量服用时,大蒜不会引起任何的副作用。(Dr. Lu)

Garlic as effective as d-penicillamine at detoxifying lead

A study published in the journal Basic & Clinical Pharmacology & Toxicology finds garlic is as effective as a common chelation drug known as d-penicillamine at detoxifying heavy metals like lead.  And garlic does not induce side effects while d-penicillamine can cause damage to multiple organs and tissues.

The study titled “Comparison of Therapeutic Effects of Garlic and d-penicillamine in Patients with Chronic Occupational Lead Poisoning” was intended to confirm previous animal studies that have already shown that garlic (allium sativum) can effectively reduce lead in the blood and tissues.

In the study, 117 workers at a car battery plant were enrolled and divided into two groups, one group assigned to take 1,000 mg of garlic extract with 1.2 milligrams of allicin), three times a day, and the other group to take 250 mg of d-penicillamine, three times daily.  The treatments lasted for four weeks.

With garlic treatment, patients experienced a significant clinical improvement in irritability, headache, and decreased deep tendon reflex and mean systolic blood pressure.  The improvement was not found in the group treated with de-penicilamine.

Also with garlic treatment, the blood lead concentrations were reduced from 426 to 347 ug/L while with d-penicillamine, the lead concentrations were reduced from 417 to 315 ug/L.  The difference was insignificant.

The side effects were more often experienced by participants in the group treated with d-penicillamine than those in the group treated with garlic.

The study concludes that garlic can be recommended as a treatment for  mild-to-moderate lead poisoning.

Globally, lead poisoning is responsible for 0.2% of all deaths and 0.6% of disability.  Exposure to toxic heavy metals like lead can harm the cardiovascular, skeletal, gastrointestinal, kidney, reproductive and nervous systems in human beings.

Infants, children and those developing nervous systems were more susceptible to lead poisoning than adults.  A study published in 2008 in PLoS finds that when people were exposed to lead in their childhood, they would have smaller brains as adults.

d-penicillamine is commonly used, but it can cause a myriad side effects including breast enlargement, bone marrow suppression, anorexia, collagen disorders, diarrhea, dyspepsia, damages to the kidney, liver and muscles.

The treatment with d-penicillamine is so toxic that 30 to 60% of patients experience side effects.  By contrast, garlic used in the dose indicated poses zero risk.

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