怀孕期间中度至重度饮酒会改变新生儿,母亲的基因 Moderate to heavy drinking during pregnancy alters genes in newborns, mothers

根据罗格斯大学领导的一项研究,在怀孕期间饮用中度至高度酒精的母亲可能正在改变婴儿的DNA。

“我们的研究结果可能使孩子更容易接受产前酒精暴露测试,并能够帮助改善儿童生活的早期诊断和干预,”主要作者Dipak K. Sarkar说.萨卡尔是位于罗格斯大学NEWBRUNSWICK分校的动物系的杰出教授和该系的内分泌项目主任。。
萨卡尔和同事在一项关于胎儿酒精谱系障碍的合作倡议中进行的研究发表在“酒精中毒:临床和实验研究”杂志上。

在罗格斯大学领导的早期研究中发现暴饮暴食和大量饮酒可能引发成人长期的遗传变化,研究人员在30名孕妇和359名儿童中寻求酒精诱导的DNA变化。

他们在怀孕期间饮用中度至高度酒精的女性和在子宫里暴露于这些酒精水平的儿童中发现两个基因发生了变化 – 一个是调节应激反应系统的POMC和影响身体生物钟的PER2。

该研究定义在一个月内五次或五次以上每次饮酒四杯为重度饮酒。一个月饮用三杯或三杯以下为中度饮酒。(编者注:任何量的酒精都可以造成对小孩的伤害.)

“我们的研究可能有助于科学家识别生物标记物 – 可测量的指标,如改变的基因或蛋白质 – 预测产前酒精暴露的风险,”萨卡说。

胎儿酒精谱系障碍可包括身体或智力残疾以及行为和学习问题。根据美国疾病控制和预防中心的说法,尽管没有治愈方法,早期干预治疗服务可以改善儿童的发育,该中心表示,怀孕期间没有已知的安全饮酒量。

该研究还发现,子宫内暴露于酒精中的婴儿 – 从母亲的血液中通过脐带 – 会增加皮质醇水平,皮质醇是一种潜在的有害压力激素,可以抑制免疫系统并导致持续的健康问题。

NEWS RELEASE 

Moderate to heavy drinking during pregnancy alters genes in newborns, mothers

Rutgers-led research could help lead to tests for prenatal exposure to alcohol and related health issues

RUTGERS UNIVERSITY

IMAGE
IMAGE: RESEARCHERS LOOKED FOR ALCOHOL-INDUCED DNA CHANGES IN PREGNANT WOMEN AND THEIR CHILDREN. THEY FOUND CHANGES TO TWO GENES — POMC, WHICH REGULATES THE STRESS-RESPONSE SYSTEM, AND PER2, WHICH INFLUENCES THE… view more 

CREDIT: SYANI MUKHERJEE/RUTGERS UNIVERSITY-NEW BRUNSWICK

Mothers who drink moderate to high levels of alcohol during pregnancy may be changing their babies’ DNA, according to a Rutgers-led study.

“Our findings may make it easier to test children for prenatal alcohol exposure – and enable early diagnosis and intervention that can help improve the children’s lives,” said lead author Dipak K. Sarkar, a Distinguished Professor and director of the Endocrine Program in the Department of Animal Sciences at Rutgers University-New Brunswick.

The study by Sarkar and scientists in a Collaborative Initiative on Fetal Alcohol Spectrum Disorders is in the journal Alcoholism: Clinical and Experimental Research.

Building on an earlier Rutgers-led study that found binge and heavy drinking may trigger long-lasting genetic change in adults, the researchers sought alcohol-induced DNA changes in 30 pregnant women and 359 children.

They found changes to two genes – POMC, which regulates the stress-response system, and PER2, which influences the body’s biological clock – in women who drank moderate to high levels of alcohol during pregnancy and in children who had been exposed to those levels of alcohol in the womb.

Heavy drinking in women is four or more drinks on at least five occasions in a month. Moderate drinking in women is about three drinks per occasion.

“Our research may help scientists identify biomarkers – measurable indicators such as altered genes or proteins – that predict the risks from prenatal alcohol exposure,” Sarkar said.

Fetal alcohol spectrum disorders can include physical or intellectual disabilities as well as behavioral and learning problems. While there is no cure, early intervention treatment services can improve a child’s development, according to the U.S. Centers for Disease Control and Prevention, which says there is no known safe amount of alcohol to drink while pregnant.

The study also found that infants exposed to alcohol in the womb – which passes from the mother’s blood through the umbilical cord – had increased levels of cortisol, a potentially harmful stress hormone that can suppress the immune system and lead to ongoing health issues.

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