健康的高纤维饮食降低先兆子痫的风险 Healthy high-fiber diet reduces Preeclampsia risk

一个健康的饮食富含纤维的一般建议,但新的研究表明,它可能是更重要的是在怀孕期间,以促进母亲和孩子的福祉。

植物纤维在肠道中被细菌分解成影响免疫系统的因素。

研究人员从悉尼大学的查尔斯*珀金斯中心,Barwon婴儿研究从迪肯大学,莫纳什大学,詹姆斯*库克大学和澳大利亚国立大学合作,调查这些代谢产物的肠道细菌在怀孕期间的作用。

这项研究的资深作者Ralph Nanan教授说,简单的建议”吃真正的食物,主要是植物,而不是太多”可能是我们这个时代最严重的情况下最有效的初级预防策略。

悉尼大学医学院(University Of Sydney School Of Medicine)和查尔斯*帕金斯中心(Charles Perkins Centre)的南安教授说:”母亲的肠道细菌和饮食似乎对促进健康怀孕至关重要。

今天发表在Nature Communications上的研究发现,在人类中,醋酸盐的水平降低,这主要是由肠道中的纤维发酵产生的,与常见的和严重的妊娠相关的先兆子痫有关。

先兆子痫发生在多达10%的怀孕,特点是血压高,尿液中的蛋白质和母亲的严重肿胀。 它也干扰了孩子的免疫发展,而在子宫内,与一些证据表明过敏和自身免疫性疾病的更高利率以后在生活中的链接。

目前的研究发现,先兆子痫影响了一个重要的胎儿免疫器官,胸腺,它位于胸骨后面的发展。

胎儿在preeclamptic怀孕被发现有一个更小的胸腺比儿童从健康怀孕。

胸腺通常产生的细胞,称为T细胞(胸腺来源的细胞)-特别是那些与预防过敏和自身免疫性疾病如糖尿病相关的细胞-在分娩后甚至四年后,在先兆子痫后的婴儿中也保持较低。

醋酸对发展中国家的胎儿免疫系统的机制进一步审查了单独的实验,涉及表明醋酸是驱动胎儿胸腺和T细胞发展的中心的小鼠。

总之,这些结果表明,促进特定的代谢产物的肠道细菌在怀孕期间可能是一个有效的方法来维持一个健康的怀孕,并防止过敏和自身免疫性疾病的生活

他们也许,部份地,解释过敏和autoimmune情况迅速增量因为西部饮食由高度加工的食物越来越占主导地位,是非常低的在纤维。

“迫切需要更多的研究,以了解我们如何能够最好地瞄准这个系统,以减少在现代世界中日益增长的免疫相关疾病的负担,”共同作者彼得*维尔明,Barwon婴儿研究的共同领头羊,一个主要的出生队列研究正在进行的儿童健康研究单位在Barwon健康与默多克儿童研究所(MCRI)和德银大学合作。

NEWS RELEASE 

Preeclampsia risk may be reduced by a healthy high-fiber diet

Pregnancy outcomes and infant immunity linked to gut bacteria

UNIVERSITY OF SYDNEY

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IMAGE: PREGNANCY OUTCOMES AND INFANT IMMUNITY HAVE BEEN LINKED TO GUT BACTERIA.view more 

CREDIT: PIXABAY USER:STOCKSNAP

A healthy diet rich in fibre is generally recommended, but new research shows it could be even more important during pregnancy to promote the wellbeing of the mother and child.

Plant-based fibre is broken down in the gut by bacteria into factors that influence the immune system.

Researchers from the University of Sydney’s Charles Perkins Centre, the Barwon Infant Study from Deakin University, Monash University, James Cook University and the Australian National University collaborated to investigate the role of these metabolic products of gut bacteria during pregnancy.

Senior author of the study Professor Ralph Nanan said the simple recommendation to ‘eat real food, mostly plants, and not too much’ might be the most effective primary prevention strategy for some of the most serious conditions of our time.

“The mother’s gut bacteria and diet appear to be crucial to promoting a healthy pregnancy,” Professor Nanan, from the University of Sydney School of Medicine and Charles Perkins Centre, said.

Published today in Nature Communications, the study found that in humans, reduced levels of acetate, which is mainly produced by fibre fermentation in the gut, is associated with the common and serious pregnancy-related condition preeclampsia.

Preeclampsia occurs in up to 10 percent of pregnancies and is characterised by high blood pressure, protein in the urine and severe swelling in the mother. It also interferes with the child’s immune development whilst in the womb, with some evidence suggesting a link to higher rates of allergies and autoimmune disease later in life.

The current study found that preeclampsia affected the development of an important fetal immune organ, the thymus, which sits just behind the breastbone.

Fetuses in preeclamptic pregnancies were found to have a much smaller thymus than children from healthy pregnancies.

The cells the thymus normally generates, called T cells (thymus-derived cells) – specifically those associated with the prevention of allergies and autoimmune conditions such as diabetes – also remained lower in infants after preeclampsia, even four years after delivery.

The mechanisms of acetate on the developing fetal immune system were further examined in separate experiments involving mice that showed acetate was central in driving fetal thymus and T cell development.

Together, these results showed that promoting specific metabolic products of gut bacteria during pregnancy might be an effective way to maintain a healthy pregnancy and to prevent allergies and autoimmune conditions later in life.

They may also, in part, explain the rapid increase of allergies and autoimmune conditions as Western diets are increasingly dominated by highly processed foods, which are very low in fibre.

“More studies are urgently needed to understand how we can best target this system to reduce the growing burden of immune related diseases in the modern world,” said co-author Peter Vuillermin, co-lead of the Barwon Infant Study, a major birth cohort study being conducted by the Child Health Research Unit at Barwon Health in collaboration with the Murdoch Children’s Research Institute (MCRI) and Deakin University.

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Disclosures: The authors declare that they have no competing interests. The James Cook University NMR facility was partially funded by the Australian Research Council (LE120100015, LE160100218).

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