定时释放的姜黄可以阻止癌细胞的生长 Timed release of turmeric stops cancer cell growth

华盛顿州大学研究小组开发了一种药物输送系统,该系统使用姜黄素,姜黄素是香料姜黄中的主要成分,可成功抑制骨癌细胞,同时促进健康骨细胞的生长。

这项工作可以为骨肉瘤患者提供更好的术后治疗,骨肉瘤是儿童癌症死亡的第二大流行原因。研究人员,包括机械和材料工程学院的Susmita Bose,Herman和Brita Lindholm Endowed讲座教授以及研究生Naboneeta Sarkar,在ACS应用材料和接口杂志上报道了他们的工作。

患有骨癌的年轻患者通常在手术前后接受高剂量的化疗,其中许多具有有害的副作用。研究人员希望开发更温和的治疗方案,特别是在手术后患者试图从骨质损伤中恢复的同时,他们正在服用苛刻的药物来抑制肿瘤生长。

几个世纪以来,姜黄在亚洲国家已被用于烹饪和作为药物,其活性成分姜黄素已被证明具有抗氧化,抗炎和骨骼建造能力。它还被证明可以预防各种形式的癌症。

“我希望人们知道这些天然化合物的有益作用,”Bose说。 “源自这些基于植物的产品的天然生物分子价格低廉,是合成药物的更安全的替代品。”

然而,当作为药物口服时,该化合物在体内不能很好地被吸收。它被代谢并消除得太快。

在他们的研究中,研究人员使用3D打印来建立磷酸钙支撑架。虽然大多数植入物目前由金属制成,但这种陶瓷支架更像真骨,有朝一日可用作骨癌手术后的移植材料。研究人员将包裹在脂肪分子囊泡中的姜黄素掺入支架中,使化学物质逐渐释放。

研究人员发现,与未经处理的样本相比,他们的系统在11天后抑制了骨肉瘤细胞的生长96%。该系统还促进了健康的骨细胞生长。

“这项研究引入了一个新的整合时代 – 现代3D打印技术与安全有效地使用替代医学相结合,可为骨组织工程提供更好的工具,”Bose说

News Release 

Timed release of turmeric stops cancer cell growth

Washington State University

PULLMAN, Wash. – A Washington State University research team has developed a drug delivery system using curcumin, the main ingredient in the spice turmeric, that successfully inhibits bone cancer cells while promoting growth of healthy bone cells.

The work could lead to better post-operative treatments for people with osteosarcoma, the second most prevalent cause of cancer death in children.

The researchers, including Susmita Bose, Herman and Brita Lindholm Endowed Chair Professor in the School of Mechanical and Materials Engineering, and graduate student Naboneeta Sarkar, report on their work in the journal, ACS Applied Materials and Interfaces.

Young patients with bone cancer are often treated with high doses of chemotherapy before and after surgery, many of which have harmful side effects. Researchers would like to develop gentler treatment options, especially after surgery when patients are trying to recover from bone damage at the same time that they are taking harsh drugs to suppress tumor growth.

Turmeric has been used in cooking and as medicine for centuries in Asian countries, and its active ingredient, curcumin has been shown to have anti-oxidant, anti-inflammatory and bone-building capabilities. It has also been shown to prevent various forms of cancers.

“I want people to know the beneficial effects of these natural compounds,” said Bose. “Natural biomolecules derived from these plant-based products are inexpensive and a safer alternative to synthetic drugs.”

However, when taken orally as medicine, the compound can’t be absorbed well in the body. It is metabolized and eliminated too quickly.

In their study, the researchers used 3D printing to build support scaffolds out of calcium phosphate. While most implants are currently made of metal, such ceramic scaffolds, which are more like real bone, could someday be used as a graft material after bone cancer surgery. The researchers incorporated curcumin, encapsulated in a vesicle of fat molecules into the scaffolds, allowing for the gradual release of the chemical.

The researchers found that their system inhibited the growth of osteosarcoma cells by 96 percent after 11 days as compared to untreated samples. The system also promoted healthy bone cell growth.

“This study introduces a new era of integration – where modern 3d printing technology is coupled with the safe and effective use of alternative medicine, which may provide a better tool for bone tissue engineering,” said Bose.

###

The researchers are continuing the unique area of research, studying the benefits of integrating other natural compounds in biomedical technology. The work was funded by the National Institutes of Health.

$$$ 如果你愿意,你可以在这捐款支持我们。谢谢。$$$
$$$ If you would, you can make a donation here to support us. Thank you. $$$

18

No Responses

Write a response