Electromagnetic radiation from mobile phones can increase the risk of cancer 手机电磁辐射可以增加癌症的风险

Research published in 2010 showed that microwave or electromagnetic radiation emitted from mobile phones inhibited the formation of tumor suppressor TP53 binding protein 1 (53BP1) foci, which is the repair of DNA double-strand breaks in human primary fibroblasts and mesenchymal stem cells Markers of activity. This finding is consistent with what was found in previous studies by the same author and human lymphocytes.

Specifically, scientists found that the GSM (Global System for Mobile Communications) carrier frequency of 915 MHz and the UMTS (Universal Global Telecommunication System) frequency of 1947.4 MHz induced the inhibition of 53BP1 foci in two types of cells-human primary growth. Fibroblasts and mesenchymal stem cells. However, the GSM carrier frequency of 905 MHz only affects stem cells. Inhibition of 53BP1 foci can reduce the ability of cells to properly repair DNA double-strand breaks.

DNA double-strand breaks and their error repair in stem cells are thought to be important for the occurrence of various leukemias and other malignant tumors. When exposed to ionizing radiation, a known carcinogen, known cells have increased amounts of DNA double-strand breaks and 53BP1 foci. It is natural to increase the number of 53BP1 lesions to repair DNA double-strand breaks. It is known that many cancers including leukemia are also caused by mutated stem cells, which is also the cause of metastasis of various cancers.

This study shows that exposure to electromagnetic radio frequencies emitted from radio towers and cell phones may increase the risk of cancers such as leukemia and brain cancer. Previous studies of long-term mobile phone users (more than 10 years) have found that the link between long-term use of mobile phones and the risk of glioma is greatly increased-a fatal brain cancer, even if short-term studies have not found such a link. (David Liu)

瑞典，斯洛伐克共和国和俄罗斯的科学家进行了一项研究，并发现证据表明手机(mobile phones)电磁辐射可能会导致各种癌症，包括白血病 (leukemia)和胶质瘤(glioma)。

2010年发布的研究表明，从手机发射的微波或电磁辐射抑制了肿瘤抑制物TP53结合蛋白1（53BP1）灶的形成，这是人类原代成纤维细胞和间充质干细胞中DNA双链断裂修复活性的标志物。这一发现与以前由同一作者与人类淋巴细胞引起的研究中发现的一致。

具体来说，科学家发现在915 MHz的GSM（全球移动通信系统）载波频率和1947.4 MHz的UMTS（通用全球通信系统）频率诱导了两种类型的细胞中的53BP1灶的抑制 – 人原发性成纤维细胞和间充质干细胞。但是，905 MHz的GSM载波频率只影响干细胞。抑制53BP1灶可以降低细胞正确修复DNA双链断裂的能力。

DNA双链断裂及其在干细胞中的错误修复被认为对各种白血病和其他恶性肿瘤的发生很重要。当暴露于已知的致癌物 – 电离辐射时，已知细胞具有增加量的DNA双链断裂和53BP1灶。天然需要增加53BP1病灶的数量来修复DNA双链断裂。已知许多癌症包括白血病也是由突变的干细胞引起的，这也是各种癌症转移(metastasis)的原因。

这项研究表明，从无线电塔和手机发射的电磁射频的暴露可能会增加像白血病和脑癌等癌症的风险。以前对长期手机用户的研究（10多年）已经发现长期使用手机之间的联系和胶质瘤的风险大大增加 – 一种致命的脑癌，即使短期研究没有发现这样的联系。(刘大卫)

Citation: Markovà E, Malmgren LO, Belyaev IY 2010. Microwaves from Mobile Phones Inhibit 53BP1 Focus Formation in Human Stem Cells More Strongly Than in Differentiated Cells: Possible Mechanistic Link to Cancer Risk. Environ Health Perspect 118:-. doi:10.1289/ehp.0900781