运动有益于那些开始接受癌症治疗的患者 Exercise works for those beginning cancer treatment

News Release 11-Mar-2020

James Cook University

Associate Professor Anthony Leicht was part of an international group led by Professor John Saxton from Northumbria University and the University of East Anglia that studied how exercise might help prostate cancer sufferers who were about to start Androgen Deprivation Therapy (ADT).

The initial treatment for sufferers involves using drugs or surgery to reduce the level of androgen hormones, which prostate cancer cells usually require to multiply.

“The problem is ADT has several side-effects, including increased body fat, decreased cardiopulmonary fitness and increased fatigue. These can increase the risk of a cardiovascular event and reduce health-related quality of life,” said Dr Leicht.

The research team tested 50 people to see if supervised exercise sessions could help reduce the side-effects of ADT and how long any benefits lasted after the exercise supervision was withdrawn.

“The exercise group completed three months of supervised aerobic and resistance exercise training involving two sessions a week for 60 minutes, followed by three months of self-directed exercise,” said Dr Leicht.

The team found the exercise programs produced sustained benefits in patients’ cardiovascular risk profile and quality of life. Differences in cardiopulmonary fitness and fatigue, however, did not continue after the period of supervised exercise ended.

“What was important, and different from most other studies, was that the patients started the exercise program before the ADT treatment began. Other studies have examined patients already undergoing treatment,” Dr Leicht said.

“Secondly, we followed up during the period of self-directed exercise and found some of the benefits were ongoing.”

Sustaining the exercise program was important because ADT side-effects continue to develop after the first three months of treatment.

“In older people we often see reductions in strength and physical function just three months after halting supervised exercise. They may stop exercising because of cost or other reasons.

“A more pragmatic approach such as home-based exercise or a shorter period of supervision with follow-on remote support could help get around these restrictions and provide measurable benefits to prostate cancer sufferers.”

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2362/5000新闻稿2020年3月11日
锻炼适合那些开始接受癌症治疗的人

詹姆斯·库克大学

Anthony Leicht副教授是由诺森比亚大学和东英吉利大学的John Saxton教授领导的国际小组的成员，该小组研究了运动如何帮助即将开始雄激素剥夺疗法（ADT）的前列腺癌患者。

对患者的初始治疗包括使用药物或手术以降低雄激素的水平，而前列腺癌细胞通常需要这种水平才能繁殖。

Leicht博士说：“问题在于，ADT具有多种副作用，包括增加体内脂肪，降低心肺适应性和增加疲劳。这些副作用可能增加发生心血管事件的风险并降低与健康有关的生活质量。”

研究小组对50人进行了测试，以了解有监督的锻炼是否可以帮助减轻ADT的副作用，以及撤消运动监督后任何益处持续了多长时间。

莱希特博士说：“运动组完成了三个月的有氧运动和阻力运动的监督训练，每周两次，每次60分钟，然后进行三个月的自我指导运动。”

研究小组发现，锻炼计划对患者的心血管风险状况和生活质量产生了持续的好处。但是，在有监督的运动期结束后，心肺健康和疲劳的差异并未继续。

莱希特博士说：“重要的是，与大多数其他研究不同的是，患者在ADT治疗开始之前就开始了锻炼计划。其他研究已经检查了已经接受治疗的患者。”

“其次，我们在自我指导的锻炼期间进行了随访，发现其中一些好处正在持续。”

维持锻炼计划很重要，因为在治疗的头三个月后，ADT的副作用继续发展。

“在老年人中，在停止有监督的运动后仅三个月，我们经常会看到力量和身体机能下降。由于成本或其他原因，他们可能会停止运动。

“一种更务实的方法，例如家庭锻炼或较短的监督期以及后续的远程支持，可以帮助克服这些限制，并为前列腺癌患者提供可衡量的益处。”

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