Secondhand smoke appears to heighten risk of oral cancer 二手煙似乎增加了口腔癌的風險

News Release 26-Apr-2021

Editor’s note: Smoking, first hand or second hand, can cause more than lung cancer. Oral cancer is not the only additional malignancy that the second smoke can induce. To say the least, it can also cause breast caner. Heart disease and stroke can be another big hit.

編者註：第一手或第二手吸煙會導致肺癌。 口腔癌不是第二種煙霧可以誘發的唯一的其他惡性腫瘤。 至少可以說，它也會引起乳腺癌。 二手煙也可能增加心髒病和中風的風險。

More effective secondhand smoke prevention programmes needed to protect public health, say researchers

BMJ

Research News

People who are exposed to secondhand smoke could have a 51% higher risk of developing oral cancer, suggests a review of existing research published online in the journal Tobacco Control.

Oral cancers – lip, oral cavity and oropharynx cancers – account for 447,751 new cases of cancer and 228,389 deaths every year globally. Significant risk factors for these forms of cancer include tobacco smoking and use of smokeless tobacco, consumption of alcohol, and betel quid chewing.

Tobacco smoke forms the largest exposure of humans to chemical carcinogens and it causes one out of five cancer-related deaths in the world.

However, it is not only active smokers affected as, according to data from 192 countries, 33% of male non-smokers, 35% of female non-smokers and 40% of children were exposed to involuntary smoking during one year by inhaling secondhand tobacco smoke.

Previous research has shown that inhaling secondhand smoke causes several diseases, including lung cancer. Although tobacco smoking is a known cause of oral cancer, it has not yet been established whether or not secondhand smoke also causes oral cancer.

So an international team of researchers from Portugal, UK, Spain, and the USA, set out to evaluate if there was a potential association between secondhand smoke exposure and the risk of oral cancer.

They reviewed and analysed five existing relevant studies involving 6,977 people collectively of whom 3,452 were exposed to secondhand smoke and 3,525 were not. These studies had been carried out in Asia, Europe, North America and Latin America.

Analysis showed that people who were exposed to secondhand smoke had a 51% higher risk of developing oral cancer.

In addition, the duration of exposure of more than 10 or 15 years increased the risk of oral cancer to more than twice compared with non-exposed individuals.

The authors acknowledge that their analysis only involved a small number of studies, but that several of the original studies had already pooled many individual studies so the overall number of cases and controls for the new meta-analyses was high.

As such, they conclude: “This systematic review and meta-analysis supports a causal association between secondhand smoke exposure and oral cancer. Moreover, the analyses of exposure response, including by duration of exposure (more than 10 or 15 years) to secondhand smoke, further supports causal inference.”

They add: “The identification of the harmful effects of secondhand smoke exposure provides guidance to public health professionals, researchers, and policymakers as they develop and deliver effective secondhand smoke exposure prevention programmes and adopt appropriate measures to implement guidelines in Article 8 of the WHO’s [World Health Organization] Framework Convention on Tobacco Control.”

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Externally peer reviewed? Yes
Evidence type: Data review and analysis
Subjects: People and secondhand smoke