动物研究发现,椰子油可减少肥胖女性的代谢综合症 Coconut oil reduces features of metabolic syndrome in obese females, animal study finds

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News Release 31-Mar-2020

The Endocrine Society

WASHINGTON–Obese females that ate a small amount of coconut oil daily, even as part of a high-fat diet, had decreased features of metabolic syndrome, a cluster of risk factors that raise the chances of developing diabetes, heart disease and stroke, an animal study finds. The study results were accepted for presentation at ENDO 2020, the Endocrine Society’s annual meeting, and will be published in a special supplemental section of the Journal of the Endocrine Society.

“Our controlled experimental study suggests that coconut oil may not be bad for cardiometabolic health, contrary to what previous studies have concluded,” said the study’s lead investigator, Annie Newell-Fugate, D.V.M., Ph.D., an assistant professor at Texas A&M University in College Station, Texas.

Nearly 40% of U.S. adults meet the criteria for obesity, the Centers for Disease Control and Prevention reports. One in five Americans has metabolic syndrome, which is linked partly to obesity, according to the Endocrine Society’s Hormone Health Network. Adding to the problem, Newell-Fugate said, is that the typical Western diet may contain 40% or more fat.

The researchers wanted to learn whether eating a small amount of coconut oil could improve metabolism, despite consumption of a Western-style diet in which 49% of daily calories came from fat. Their study used an animal model of reproductive-age women with obesity and metabolic syndrome: sexually mature, female mini-pigs fed a high-fat, high-fructose diet resembling a Western diet. For eight months, two groups of pigs ate this high-fat diet consisting of 4,500 calories a day, but the groups differed by the type of one saturated fat. One group’s food included 5% animal lard, which Newell-Fugate said some U.S. regions and ethnic cultures commonly use for cooking. The other high-fat diet group received 5% nonorganic coconut oil instead of lard in their food. A third group of pigs ate a low-calorie, lean diet as a control.

Although both groups fed the high-fat diet became obese, the pigs that received coconut oil had lower cholesterol and blood glucose (sugar) levels compared with the pigs that ate the lard-supplemented diet, Newell-Fugate reported. Also, the coconut oil group had less evidence of fatty liver disease and less deep belly fat than the lard group.

“Our research suggests that coconut oil may be used with lifestyle modifications and anti-diabetic drugs to treat metabolic syndrome, at least in women with obesity,” Newell-Fugate said. She added that they do not know if their findings also apply to men.

Coconut oil is available in many grocery stores and could substitute for other saturated fats in small quantities, she suggested. “Substituting one tablespoon of your saturated fat calories per day with coconut oil could result in an improvement in your cardiometabolic health,” Newell-Fugate said.

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A National Institutes of Health Research Career Development Award to Newell-Fugate funded this research, which received no industry support.

The Endocrine Society canceled its annual meeting, ENDO 2020, amid concerns about COVID-19. Visit our online newsroom for more information on accepted abstracts, which will be published in a special supplemental section of the Journal of the Endocrine Society.

Endocrinologists are at the core of solving the most pressing health problems of our time, from diabetes and obesity to infertility, bone health, and hormone-related cancers. The Endocrine Society is the world’s oldest and largest organization of scientists devoted to hormone research and physicians who care for people with hormone-related conditions.

The Society has more than 18,000 members, including scientists, physicians, educators, nurses and students in 122 countries. To learn more about the Society and the field of endocrinology, visit our site at http://www.endocrine.org. Follow us on Twitter at @TheEndoSociety and @EndoMedia.

动物研究发现,椰子油可减少肥胖女性的代谢综合症

华盛顿–肥胖女性每天摄入少量椰子油,即使作为高脂饮食的一部分,其代谢综合征的特征也有所降低,而代谢综合征是一类危险因素,增加了患上糖尿病,心脏病和中风的机会,动物研究发现。研究结果在内分泌学会年会ENDO 2020上被接受,并将发表在《内分泌学会杂志》的特别增刊中。

“我们的对照实验研究表明,与先前的研究结论相反,椰子油可能对心脏代谢健康无害,”该研究的首席研究员,德州农工大学助理教授安妮·纽厄尔-富格特(DVM)博士说。德克萨斯州大学城大学。

美国疾病控制和预防中心报告说,将近40%的美国成年人符合肥胖标准。根据内分泌学会的激素健康网络,五分之一的美国人患有代谢综合症,其一部分与肥胖有关。 Newell-Fugate说,使问题更加严重的是,典型的西方饮食可能含有40%或更多的脂肪。

研究人员想知道,尽管食用西式饮食,其中每天热量的49%来自脂肪,但吃少量椰子油是否可以改善新陈代谢。他们的研究使用了患有肥胖和代谢综合症的育龄妇女的动物模型:性成熟的雌性小猪喂食类似于西方饮食的高脂,高果糖饮食。在八个月的时间里,两组猪每天吃这种含脂肪的高脂肪饲料,热量为4,500卡路里,但两组之间的差异仅在于一种饱和脂肪的类型。一组食物中含有5%的动物猪油,纽厄尔·富格特(Newell-Fugate)说,美国的某些地区和种族文化通常会用来烹饪。另一组高脂饮食组在他们的食物中接受了5%的非有机椰子油代替猪油。第三组猪吃低热量,瘦的饮食作为对照。

Newell-Fugate报道,尽管两组都以高脂饮食喂养,但是与接受猪油补充饮食的猪相比,接受椰子油的猪的胆固醇和血糖(糖)水平较低。而且,与猪油组相比,椰子油组的脂肪肝疾病证据较少,腹部深层脂肪较少。

Newell-Fugate说:“我们的研究表明,椰子油可与生活方式改变和抗糖尿病药一起使用,以治疗代谢综合症,至少在肥胖女性中如此。”她补充说,他们不知道他们的发现是否也适用于男性。

她建议,杂货店里有很多椰子油,它们可以代替少量其他饱和脂肪。 Newell-Fugate说:“每天用一汤匙的饱和脂肪卡路里代替椰子油,可以改善您的心脏代谢健康。”

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