New study shows people with a high Omega-3 index less likely to die prematurely Omega-3指數高的人不太可能過早死亡

News Release 22-Apr-2021

Editor’s note: Omega 3 fatty acids help fight against inflammation which is the root cause for all sorts of health conditions. They are used by many patients to treat cancer. One well publicized anticancer diet known as Budwig diet is based on omega 3 fatty acids rich flaxseed oil and cottage cheese. Canola oil contains some decent amounts of omega 3 fatty acids. A small amount of these omega 3 fatty acids can be converted to become DHA and EPA. But they are still healthy food components. They are cleaner than marine sourced omega 3 fatty acids which may be tainted with pollutants.

編者註:歐米茄3脂肪酸有助於抵抗炎症,這是各種健康狀況的根本原因。 它們被許多患者用來治療癌症。 一種廣為人知的抗癌飲食,稱為Budwig diet,其飲食基於富含歐米加3脂肪酸的亞麻籽油和乾酪。 菜籽油中含有一定量的歐米加3脂肪酸。 少量的這些歐米伽3脂肪酸可以轉化為DHA和EPA。 但是它們仍然是健康的食物成分。 它們比海洋來源的可能被污染物污染的歐米伽3脂肪酸更清潔。

Research shows people with a high Omega-3 Index are 13% less likely to die prematurely compared to those with a low Omega-3 Index

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A new research paper examining the relationship between the Omega-3 Index and risk for death from any and all causes has been published in Nature Communications. It showed that those people with higher omega-3 EPA and DHA blood levels (i.e., Omega-3 Index) lived longer than those with lower levels. In other words, those people who died with relatively low omega-3 levels died prematurely, i.e., all else being equal, they might have lived longer had their levels been higher.

Numerous studies have investigated the link between omega-3s and diseases affecting the heart, brain, eyes and joints, but few studies have examined their possible effects on lifespan.

In Japan, omega-3 intakes and blood levels are higher than most other countries in the world AND they happen to live longer than most. Coincidence? Possibly, or maybe a high Omega-3 Index is part of the explanation.

Studies reporting estimated dietary fish or omega-3 intake have reported benefits on risk for death from all causes, but “diet record” studies carry little weight because of the imprecision in getting at true EPA and DHA intakes. Studies using biomarkers – i.e., blood levels – of omega-3 are much more believable because the “exposure” variable is objective.

This new paper is from the FORCE – Fatty Acids & Outcomes Research – Consortium. FORCE is comprised of researchers around the world that have gathered data on blood fatty acid levels in large groups of study subjects (or cohorts) and have followed those individuals over many years to determine what diseases they develop. These data are then pooled to get a clearer picture of these relationships than a single cohort can provide. The current study focused on omega-3 levels and the risk for death during the follow-up period, and it is the largest study yet to do so.

Specifically, this report is a prospective analysis of pooled data from 17 separate cohorts from around the world, including 42,466 people followed for 16 years on average during which time 15,720 people died. When FORCE researchers examined the risk for death from any cause, the people who had the highest EPA+DHA levels (i.e., at the 90th percentile) had a statistically significant, 13% lower risk for death than people with EPA+DHA levels in the 10th percentile. When they looked at three major causes of death – cardiovascular disease, cancer and all other causes combined – they found statistically significant risk reductions (again comparing the 90th vs 10th percentile) of 15%, 11%, and 13%, respectively.

The range between the 10th and 90th percentile for EPA+DHA was (in terms of red blood cell membrane omega-3 levels, i.e., the Omega-3 Index) about 3.5% to 7.6%. From other research, an optimal Omega-3 Index is 8% or higher.

In the new paper, the authors noted that these findings suggest that omega-3 fatty acids may beneficially affect overall health and thus slow the aging process, and that they are not just good for heart disease.

“Since all of these analyses were statistically adjusted for multiple personal and medical factors (i.e., age, sex, weight, smoking, diabetes, blood pressure, etc., plus blood omega-6 fatty acid levels), we believe that these are the strongest data published to date supporting the view that over the long-term, having higher blood omega-3 levels can help maintain better overall health,” said Dr. Bill Harris, Founder of the Fatty Acid Research Institute (FARI), and lead author on this paper.

Dr. Harris co-developed the Omega-3 Index 17 years ago as an objective measure of the body’s omega-3 status. Measuring omega-3s in red blood cell membranes offers an accurate picture of one’s overall omega-3 intake during the last four to six months. To date, the Omega-3 Index has been featured in more than 200 research studies.

“This comprehensive look at observational studies of circulating omega-3 fatty acids indicates that the long chain omega-3s EPA, DPA, and DHA, usually obtained from seafood, are strongly associated with all-cause mortality, while levels of the plant omega-3 alpha-linolenic acid (ALA) are less so,” said Tom Brenna, PhD, Professor of Pediatrics, Human Nutrition, and Chemistry, Dell Medical School of the University of Texas at Austin.

###Media Inquiries:

Bill Harris, President, FARI
Email: [email protected]
Phone: +1-913-302-9433

About the Fatty Acid Research Institute (FARI):

The Fatty Acid Research Institute (FARI) is a non-profit research and education foundation. FARI was founded in order to accelerate discovery of the health effects of fatty acids, most notably, the long chain omega-3 fatty acids EPA and DHA. FARI researchers and scientists will focus single-mindedly on publishing high-quality research studies on the multiple relationships between fatty acid levels and human (and animal) health outcomes. These studies will improve the ability to predict risk for disease, and more importantly, suggest ways to reduce risk by changing our diets and/or supplementation regimens.

About the FORCE Consortium:

The Fatty Acids and Outcomes Research Consortium (FORCE) is a scientific consortium with the aim of understanding how fatty acid biomarkers relate to the risk of developing cardiovascular diseases, diabetes, obesity, cancers, chronic kidney disease, and other conditions. There are 36 prospective cohorts involved in FORCE. What is common to all is having data on blood or adipose tissue fatty acid levels at baseline.

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