怀孕期间维生素D缺乏症与多动症的风险增加有关 Vitamin D deficiency during pregnancy connected to elevated risk of ADHD

有问题,联系陆博士

University of Turku

– Alongside genotype, prenatal factors such as vitamin D deficiency during pregnancy, can influence the development of ADHD, says MD Minna Sucksdorff from the University of Turku, Finland.

The study is the first population-level research to demonstrate an association between low maternal vitamin D level in early to mid-pregnancy and an elevated risk for diagnosed attention-deficit/hyperactivity disorder ADHD in the offspring.

The study included 1,067 children born between 1998 and 1999 diagnosed with ADHD in Finland and the same number of matched controls. The data was collected before the current national recommendation in Finland for the intake of vitamin D during pregnancy, which is 10 micrograms per day throughout the year.

Vitamin D deficiency still a problem

The primary investigator, Professor Andre Sourander says that, despite the recommendations, vitamin D deficiency is still a global problem. In Finland, for example, mothers’ vitamin D intake among several immigrant groups is not at a sufficient level.

– This research offers strong evidence that a low level of vitamin D during pregnancy is related to attention deficiency in offspring. As ADHD is one of the most common chronic diseases in children, the research results have a great significance for public health, says Professor Sourander.

The study is part of a larger research project that aims to discover the connections between the mother’s health during pregnancy and ADHD in offspring. The goal is to produce information for developing preventative treatments and measures for identifying children with ADHD risk.

The study was done in collaboration between researchers from the University of Turku, Finland, and Columbia University, New York and it was funded by the National Institute of Mental Health NIHM (USA) and the Academy of Finland, and it is part of the INVEST flagship programme of the University of Turku.

In the study, the researchers used the exceptionally comprehensive Finnish Maternity Cohort (FMC) consisting of approximately 2 million serum specimens collected during the first and early second trimester of pregnancy.

芬兰图尔库大学的医学博士Minna Sucksdorff表示,除了基因型外,妊娠期维生素D缺乏等产前因素也会影响多动症的发展。

这项研究是第一项人口水平的研究,该研究证明了孕妇早期至中期的低维生素D水平与后代诊断为注意力缺陷/多动症ADHD的风险升高之间存在关联。

这项研究包括了在1998年至1999年之间出生的1,067名在芬兰被诊断患有多动症的儿童,以及相同数量的配对对照。数据是在芬兰当前的国家建议怀孕之前摄入维生素D之前收集的,全年摄入量为每天10微克。

维生素D缺乏症仍然是一个问题

首席研究员安德烈·索兰德(Andre Sourander)教授说,尽管提出了建议,但维生素D缺乏仍然是一个全球性问题。例如在芬兰,几个移民群体中母亲的维生素D摄入量不足。

–这项研究提供了有力的证据,表明怀孕期间维生素D含量低与后代注意力不足有关。 Sourander教授说,由于多动症是儿童中最常见的慢性病之一,因此研究结果对公共卫生具有重要意义。

这项研究是一个更大的研究项目的一部分,该项目旨在发现怀孕期间母亲的健康状况与后代多动症之间的联系。目的是提供信息以开发预防性治疗和措施,以识别患有多动症的儿童。

这项研究是由芬兰图尔库大学和纽约哥伦比亚大学的研究人员合作完成的,该研究由美国国家心理健康研究所NIHM(美国)和芬兰科学院资助,并且是INVEST的一部分图尔库大学的旗舰课程。

在这项研究中,研究人员使用了异常全面的芬兰产妇队列(FMC),其中包括在妊娠的前三个月和下三个月初收集的大约200万份血清标本。

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