Vitamin D levels are linked to breast cancer risk | 维生素D水平与乳腺癌风险相关

In the United States, 240,000 women are diagnosed with breast cancer each year, and approximately 40,000 women die each year from the disease and/or its effects. The situation in China is similar. One thing women can do to reduce the risk of the disease is adequate sun exposure to maintain a normal serum vitamin D concentration.

For many reasons, vitamin D has been proven to prevent breast cancer and other malignant tumors. Vitamin D regulates cell differentiation and cell growth. It can initiate cell apoptosis, thereby preventing the formation of tumors. Vitamin D also down-regulates the estrogen receptor, which is one of the reasons why vitamin D can prevent breast cancer.

A new study tracked 50,884 women between the ages of 35 and 74 and recorded cases of breast cancer. All participants were not diagnosed with breast cancer at the beginning, but they all had a breast cancer sister. Those who had sisters with breast cancer had twice the risk of breast cancer as those who had no sisters.

Compared with patients with low vitamin D levels, the researchers found that women with serum vitamin D higher than 38 ng/ml were 21% less likely to develop breast cancer. Compared with people who did not take vitamin D supplements, participants who reported vitamin D supplementation four times a week had an 11% lower risk of breast cancer.

The protective effect of vitamin D on breast cancer is particularly obvious in postmenopausal women and obese women. High levels of serum vitamin D (greater than> 38.0 ng/mL) are associated with a 28% reduction in disease risk.

To maintain vitamin D at 40 to 60 ng/ml, adults should take 5,000 IU of vitamin D3 daily. This level can be maintained through adequate daily sun exposure. Vitamin D experts believe that up to 10,000 IU of vitamin D per day is safe for adults.

In fact, some studies have shown that taking high doses of vitamin D may help treat hormone-responsive breast cancer.

A study published in The Lancet in 1989 showed that the cancer-free survival of breast cancer patients with vitamin D receptors in their tumors was significantly longer than that of cancer patients without vitamin D receptors.

The study also found that 1,25(OH)2D3 inhibited the proliferation of several human breast cancer cells in vitro.

In the study, exposing rats to carcinogens gave them breast tumors that respond to hormones. Then, the tumor-bearing rats were treated with 0.1 μg of 1α-hydroxyvitamin D 3 (vitamin D analog) three times a week. Tumor progression was significantly suppressed.

Studies have shown that vitamin D supplementation may have an inhibitory effect on receptor-positive breast cancer.

2017年8月19日星期六 (JKZX.COM) – 在美国，每年有240,000名妇女被诊断患有乳腺癌(breast cancer)，每年约有40,000名妇女死于该疾病和/或其影响。中国情况类似。妇女可以做的一件事来减少该疾病的风险是足够的阳光暴露，以维持血清维生素D的正常浓度。

由于许多原因，维生素D已被证明具有防止乳腺癌和其他恶性肿瘤的功效。维生素D调节细胞分化和细胞生长。它可以启动细胞凋亡，从而阻止肿瘤的形成。维生素D也下调了雌激素受体，这就是为什么维生素D可以预防乳腺癌的原因之一。

一项新的研究，追踪了50,884名年龄在35岁至74岁之间的女性，记录了乳腺癌病例。所有参与者在开始时，均未被诊断出患有乳腺癌，但是她们都有一个患有的乳腺癌姐妹。那些有患有乳腺癌姐妹的参与者患乳腺癌的风险是那些没有姐妹患癌的参与者的两倍。

与维生素D水平较低的患者相比，研究人员发现血清维生素D高于38 ng / ml的妇女发生乳腺癌的可能性降低21％。与没有服用维生素D补充剂的人相比， 每周报告补充维生素D四次的参与者的患乳腺癌的风险降低了11％。

维生素D对乳腺癌的保护作用在绝经后妇女和肥胖妇女中特别明显。高水平的血清维生素D（大于> 38.0ng / mL）与疾病风险降低28％相关。

要维持40至60 ng / ml的维生素D，成人每天应服用5,000 IU维生素D3。这个水平是可以通过日常充足的阳光照射来维持的。维生素D专家认为，每天高达10,000 IU的维生素D对成年人来说是安全的。

事实上，一些研究表明，服用高剂量的维生素D可能有助于治疗激素反应性乳腺癌。

1989年在柳叶刀上发表的一项研究表明，肿瘤中具有维生素D受体的乳腺癌患者的肿瘤无癌症生存期明显长于无维生素D受体癌症患者的生存期。

研究还发现1,25（OH）2D3在体外抑制几种人的乳腺癌细胞的增殖。

在研究中，将大鼠暴露于致癌剂使他们得对激素有反应的乳腺肿瘤。 然后用0.1μg的1α羟基维生素D 3（维生素D类似物）每周三次治疗有肿瘤的大鼠。 肿瘤进展显着受到抑制。

研究表明，补充维生素D可能对受体阳性的乳腺癌具有抑制作用。(刘大卫)

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