News Release 4-Mar-2020

Columbia University’s Mailman School of Public Health

A new study links being overweight in middle age and later adulthood to a greater risk of advanced prostate cancer. Jeanine Genkinger, PhD, an epidemiologist at Columbia University Mailman School of Public Health, and colleagues published the study in Annals of Oncology, the journal of the European Society for Medical Oncology and Japanese Society of Medical Oncology.

Prostate cancer is the second most common cause of cancer in men in the United States. Fewer than one in three men with advanced prostate cancer live five years beyond diagnosis.

Before this study, only a few studies examined contributing factors to advanced prostate cancer. There was an especially noticeable lack of research on the linkage between factors like weight in early adulthood, changes in weight during adulthood, and waist circumference, specifically with advanced prostate cancer risk.

Using data from 15 large studies combined together, Genkinger examined associations between body fat, height, and prostate cancer risk in 830,772 men, 51,734 of whom had been diagnosed with prostate cancer. Her study took a life-course-based approach, examining survey data collected across respondents’ lifespans to determine whether and at what age during adulthood excess body fat increased risk for advanced prostate cancer. The researchers found that a BMI elevated above a healthy weight during middle to late adulthood–median age range from 50 to 64–was linked to the greatest risk for developing advanced prostate cancer. A “healthy” weight is defined as a BMI between 21 and 25 kg/m2.

They also found that greater waist circumference was linked with increased risk of advanced prostate cancer and death. Although other studies have linked higher BMI with increased prostate cancer, this is the first study to find a positive association with waist circumference.

“These study results show that risk for advanced prostate cancer can be decreased by maintaining a ‘healthy’ weight, which is in line with guidelines by the American Cancer Society and World Cancer Research Fund. Adopting healthy eating and exercising are factors that can help maintain a healthy weight,” says Genkinger, associate professor of epidemiology at Columbia Mailman School. “This study shows that adopting and maintaining healthy weight in middle to late adulthood can especially reduce risk of advanced prostate cancer.”

###

Participating institutions include Mailman School of Public Health, Columbia University Medical Center, Harvard TH Chan School of Public Health, Harvard Medical School, National Cancer Institute, Maastricht University, American Cancer Society, Cancer Council Victoria, University of Melbourne, Fred Hutchinson Cancer Research Center, SWOG Statistical Center, Karolinska Institutet, University of Oxford, Finland National Institute for Health and Welfare, University of Hawaii Cancer Center, Johns Hopkins Bloomberg School of Public Health, Japan National Cancer Center, Uppsala University. A full list of authors is listed in the publication.

This study was funded by the National Cancer Institute at the National Institutes of Health (CA098566, CA55075), and the World Cancer Research Fund International (grant 2009/89).

3318/5000一项新的研究将中年和成年后超重与晚期前列腺癌的更大风险联系起来。哥伦比亚大学梅尔曼公共卫生学院的流行病学家Jeanine Genkinger博士及其同事在《肿瘤学年鉴》，《欧洲医学肿瘤学会和日本医学肿瘤学会》杂志上发表了这项研究。

在美国，前列腺癌是第二大常见癌症。患有晚期前列腺癌的男性中，只有不到三分之一的人活到诊断后五年。

在这项研究之前，只有少数研究检查了导致晚期前列腺癌的因素。在成年初期的体重，成年期间的体重变化和腰围等因素之间的联系上，特别是缺乏晚期前列腺癌风险的因素之间的联系尤其缺乏研究。

Genkinger使用来自15项大型研究的数据相结合，研究了830772名男性（其中51,734名被诊断患有前列腺癌）中的体脂，身高与前列腺癌风险之间的关系。她的研究采用了基于生命过程的方法，检查了受访者整个生命周期中收集的调查数据，以确定成年期过多的体脂是否以及在什么年龄增加了罹患晚期前列腺癌的风险。研究人员发现，在成年中至成年后（年龄中位数为50至64岁），BMI升高至健康体重以上与发展为晚期前列腺癌的最大风险有关。 “健康”体重定义为BMI在21至25 kg / m2之间。

他们还发现，更大的腰围与晚期前列腺癌和死亡的风险增加有关。尽管其他研究已将较高的BMI与增加的前列腺癌联系起来，但这是第一个发现与腰围呈正相关的研究。

这些研究结果表明，保持“健康”体重可以降低晚期前列腺癌的风险，这符合美国癌症协会和世界癌症研究基金会的指导方针。健康饮食和锻炼是可以帮助保持健康体重的因素。”哥伦比亚梅曼学校流行病学副教授Genkinger说。 “这项研究表明，在成年中至晚期采用并保持健康的体重可以特别降低晚期前列腺癌的风险。”

###

参与机构包括梅尔曼公共卫生学院，哥伦比亚大学医学中心，哈佛大学陈陈公共卫生学院，哈佛医学院，国家癌症研究所，马斯特里赫特大学，美国癌症学会，维多利亚癌症理事会，墨尔本大学，弗雷德·哈钦森癌症研究中心，牛津大学卡罗林斯卡研究所SWOG统计中心，芬兰牛津大学国家健康与福利研究所，夏威夷大学癌症中心，约翰·霍普金斯·彭博公共卫生学院，日本乌普萨拉大学国家癌症中心。出版物中列出了作者的完整列表。

这项研究由美国国立卫生研究院的国家癌症研究所（CA098566，CA55075）和世界癌症研究基金会国际（2009/89拨款）资助。