Cholesterol lowering statins may reduce COVID-19 severity 降低膽固醇的他汀類藥物可能會降低 COVID-19 的嚴重程度

Thursday 07/15/2021 (jkzx.com/) — University of California San Diego researchers analyzed medical records from a national registry and confirmed earlier findings that statins may drastically reduce adverse outcomes from SARS-CoV-2 infection or covid 19 infection.

In the study published July 15, 2021 in PLOS ONE, researchers have found patients taking statin medications were 41 percent less likely to die from covid 19 in hospitals.

The current study essentially confirmed prior research conducted at University of California San Diego Health in 2020, which already indicated that statins may relieve the severity of covid 19.

Prescribed statins are commonly used to lower cholesterol and 93% of patients who need to lower their cholesterol take statins, according to the Centers for Disease Control and Prevention. The medications reduce blood cholesterol levels by blocking liver enzymes that make cholesterol.

It is speculated that statins may affect ACE2 receptors. If ACE2 receptors are blocked, then the covid 19 virus could not trigger the viral reaction that leads to high blood pressure which leads to respitory failures.

“At the time, we thought that statins may inhibit SARS-CoV-2 infection through their known anti-inflammatory effects and binding capabilities, which could potentially stop progression of the virus,” said Lori Daniels, MD, lead study author, professor and director of the UC-San Diego Cardiovascular Intensive Care Unit.

However,  Behnood Bikdeli, MD, a cardiologist at Brigham and Women’s Hospital in Boston and colleagues conducted a trial and found that taking 20 milligrams (mg) daily of a statin called atorvastatin for 30 days did not lower risk of death from covid 19.

The study was presented at the American College of Cardiology’s (ACC) 70th Annual Scientific Session and Expo. (Dr. Lu)

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