Contact Dr. Lu for information about cancer treatments。聯繫盧博士,獲取有關癌症治療資訊。
New discovery on how omega-3 fatty acids can reduce atherosclerosis | 關於omega-3脂肪酸如何減少動脈粥樣硬化的新發現
Contact Dr. Lu for information about cancer treatments。聯繫盧博士,獲取有關癌症治療資訊。
NEWS RELEASE
KAROLINSKA INSTITUTET
Cardiovascular disease is the most common cause of death globally and a serious public health problem. Atherosclerosis is associated with chronic inflammation in the blood vessels. Inflammation a is normally controlled by stop signals called resolvins, which switch off the inflammation and stimulate tissue healing and repair through a process called resolution of inflammation. Resolvins are formed from omega-3 fatty acids and bind to and activate a receptor called GPR32.
“We’ve found that this receptor is dysregulated in atherosclerosis, indicating a disruption in the body’s natural healing processes,” says the study’s first author Hildur Arnardottir, assistant professor at the Department of Medicine, Solna, Karolinska Institutet. “This discovery can pave the way for completely new strategies for treating and preventing atherosclerosis by arresting inflammation in the blood vessels, while also turning on the body’s healing processes with the help of omega-3 fatty acids, for example.”
The new study shows that signalling via the receptor actively stops inflammation in atherosclerotic blood vessels and stimulates healing. The researchers have studied atherosclerotic plaque and created a new experimental model with an over-expressed GPR32 receptor. The GPR32 receptor counteracted atherosclerosis and inflammation in the blood vessels, and resolvins that activate GPR32 enhanced the effect.
“We’ll now be studying the mechanisms behind the failed management of inflammation in the blood vessels and how omega-3 mediated stop signals can be used to treat atherosclerosis,” says the study’s last author Magnus Bäck, senior consultant cardiologist and professor at the Department of Medicine, Solna, Karolinska Institutet.
The study was mainly financed by the Swedish Research Council, the Swedish Heart-Lung Foundation, King Gustaf V and Queen Victoria’s Foundation of Freemasons and Region Stockholm. There are no reported conflicts of interest.
Publication: “The resolvin D1 receptor GPR32 transduces inflammation-resolution and atheroprotection”. Hildur Arnardottir, Silke Thul, Sven-Christian Pawelzik,Glykeria Karadimou, Gonzalo Artiach, Alessandro L. Gallina, Victoria Mysdotter, Miguel Carracedo, Laura Tarnawski, April S. Caravaca, Roland Baumgartner, Daniel F.J. Ketelhuth, Peder S. Olofsson, Gabrielle Paulsson-Berne, Göran K. Hansson, Magnus Bäck. The Journal of Clinical Investigation, 15 December 2021, doi: 10.1172/JCI142883.
JOURNAL
Journal of Clinical Investigation
METHOD OF RESEARCH
Experimental study
ARTICLE TITLE
“The resolvin D1 receptor GPR32 transduces inflammation-resolution and atheroprotection”
ARTICLE PUBLICATION DATE
15-Dec-2021
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刘 大卫
Trust God, not sinful people. Worship God, but not things/people. Let God lead you, but not let others lead you. 相信上帝,而不是有罪的人。 敬拜神,而不是事/人。 讓上帝帶領你,但不要讓別人帶領你。