Oncotarget: Scent test to screen for early-stage pancreatic cancer | 氣味測試篩查早期胰腺癌

News Release

Similar to sniffer dogs, the use of Caenorhabditis elegans has been introduced as a new strategy for detecting cancer-associated scents during cancer screening

Peer-Reviewed Publication

Impact Journals LLC

Scent test using Caenorhabditis elegans for the diagnosis of early pancreatic ductal adenocarcinoma.
image: The chemotaxis index was measured in 11 early pancreatic ductal adenocarcinoma cases and 17 healthy volunteers. view more 

Credit: Correspondence to – Hideshi Ishii – [email protected]

Oncotarget published “Scent test using Caenorhabditis elegans to screen for early-stage pancreatic cancer” which reported that although early detection and diagnosis are indispensable for improving the prognosis of patients with pancreatic cancer, both have yet to be achieved. Except for pancreatic cancer, other cancers have already been screened through scent tests using animals or microorganisms, including Caenorhabditis elegans.

In this study, the authors organized a nationwide study group comprising high-volume centers throughout Japan to collect patients with very-early-stage pancreatic cancer. They initially performed an open-label study involving 83 cases, with subsequent results showing significant differences after surgical removal in stage 0–IA. Preoperative urine samples had a significantly higher chemotaxis index compared to postoperative samples in patients with pancreatic cancer and healthy volunteers.

Dr. Hideshi Ishii from The Osaka University said, “Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest diseases, with a five-year survival rate of 9%.

Similar to sniffer dogs, the use of Caenorhabditis elegans has been introduced as a new strategy for detecting cancer-associated scents during cancer screening. This biological diagnosis had a reported sensitivity of 95.8%, which was also acceptable even in patients in early-stage of cancer. Furthermore, reports have shown that this test demonstrated high sensitivity in cases of gastrointestinal cancers and negative changes in the postoperative period. Moreover, this test could discriminate urine in a mouse model of pancreatic cancer.

Therefore, this method may be useful for detecting patients with early PDAC. However, how study has yet utilized this method to detect very-early-stage PDAC mainly due to the extreme difficulty of collecting urine samples from such patients. In the present study, they organized a nationwide clinical group that comprised high-volume centers throughout Japan and prospectively collected serum and urine samples from patients with very-early-stage PDAC to investigate the clinical value of a cancer detection system involving C. elegans.

The Ishii Research Team concluded in their Oncotarget Research Output, “the current study observed higher chemotaxis of C. elegans in patients with very-early-stage PDAC, suggesting its potential for use as a standard method for detecting early-stage cancer. Nonetheless, the underlying mechanisms for this chemotaxis should be clarified in order to obtain information that could help elucidate the biological characteristics of cancer.

Sign up for free Altmetric alerts about this article

DOI – https://doi.org/10.18632/oncotarget.28035

Full text – https://www.oncotarget.com/article/28035/text/

Correspondence to – Hideshi Ishii – [email protected]

Keywords – Caenorhabditis elegansearly-stage pancreatic cancerscent testbiomarkerdiagnosis

About Oncotarget

Oncotarget is a biweekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology.

To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with:

SoundCloud – https://soundcloud.com/oncotarget
Facebook – https://www.facebook.com/Oncotarget/
Twitter – https://twitter.com/oncotarget
LinkedIn – https://www.linkedin.com/company/oncotarget
Pinterest – https://www.pinterest.com/oncotarget/
Reddit – https://www.reddit.com/user/Oncotarget/

Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls

Media Contact
[email protected]
18009220957×105

Copyright © 2021 Impact Journals, LLC
Impact Journals is a registered trademark of Impact Journals, LLC


$$$ 如果你愿意,你可以在这捐款支持我们。谢谢。$$$
$$$ If you would, you can make a donation here to support us. Thank you. $$$

66

No Responses

Write a response

eight − 4 =