Researchers uncover new details behind inflammation that promotes heart disease | 研究人員發現引發心髒病的炎症背後的新細節

Editor’s note:  We are often times mistaken that inflammation is bad or harmful.  We need to understand that anything the Creator put in our body serves a purpose.  Inflammation as a physiological process is needed. For instance, inflammation can be triggered by injury inflicted on tissues.  Inflammation generates compounds that help heal the injured tissues.  So first thing to know is that inflammation is not necessarily harmful.  However, the cause that triggers the inflammation can be harmful.  For example, any injury that cause inflammation is not desired and should be avoided.  When the cause is eliminated, one needs no inflammation.
編者按:我們經常誤認為炎症是有害的或有害的。 我們需要明白,造物主放入我們身體的任何東西都是有目的的。 炎症作為一種生理過程是需要的。 例如,炎症可以由對組織造成的損傷引發。 炎症會產生有助於治愈受傷組織的化合物。 所以首先要知道的是,炎症不一定有害。 然而,引發炎症的原因可能是有害的。 例如,任何導致炎症的傷害都是不希望的,應該避免。 當原因消除後,人們不需要發炎。
News Release

Bone marrow factors lead to increased production of white blood cells that drive inflammation in cardiovascular disease.

Peer-Reviewed Publication

Massachusetts General Hospital

BOSTON – High cholesterol and inflammation are key drivers of heart disease, and an inflamed buildup of lipids can cut off the blood supply through a coronary artery to cause a heart attack. Because white blood cells, which usually defend against infection, trigger inflammation in these situations, a team led by scientists at Massachusetts General Hospital (MGH) recently studied aspects related to the cells’ production. The group’s insights, which are published in Nature Cardiovascular Research, could lead to new strategies to protect cardiovascular health.

“In patients with heart disease, white blood cells are more numerous,” says senior author Matthias Nahrendorf, MD, PhD, an investigator in MGH’s Center for Systems Biology and a professor of radiology at Harvard Medical School. “Many of these cells can be found in a plaque—the buildup of fats, cholesterol, and other substances in a blood vessel—where they arrive after being born in the bone marrow and migrating through the blood stream. But what leads to their increased bone marrow output is not clear.”

Through experiments conducted in human bone marrow and mice, Nahrendorf and his colleagues found that high blood pressure, atherosclerosis, and the occurrence of a heart attack each can cause changes in the number of blood vessels in the bone marrow. These hallmarks of cardiovascular disease also changed the bone marrow vessels’ structure and function and affected their release of factors that regulate white blood cell production and migration.

“As a consequence, more white blood cells were available in the body, and this increase, called leukocytosis, propels inflammation everywhere, including in the arteries and the heart,” explains Nahrendorf. “This study will allow us to now examine how to reduce white blood cell production to normal values, thereby cooling off inflamed plaques anywhere in the body.”

Co-authors include MGH’s David Rohde, MD, Katrien Vandoorne, PhD and others.

Funding for the study was provided by the National Heart, Lung, and Blood Institute grant P01HL142494.

“This study provides strong evidence that cardiovascular disease affects the bone marrow vasculature and consequently blood stem cell activity,” said Michelle Olive, Ph.D., program officer in the Division of Cardiovascular Sciences at the National Heart, Lung, and Blood Institute, part of the National Institutes of Health. “This work sheds new light on the important role played by the vascular bone marrow niche and how inflammation occurs.  It could lead to new targets and treatments for heart disease, the leading cause of death.”

About the Massachusetts General Hospital

Massachusetts General Hospital, founded in 1811, is the original and largest teaching hospital of Harvard Medical School. The Mass General Research Institute conducts the largest hospital-based research program in the nation, with annual research operations of more than $1 billion and comprises more than 9,500 researchers working across more than 30 institutes, centers and departments. In August 2021, Mass General was named #5 in the U.S. News & World Report list of “America’s Best Hospitals.”



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