Some colorectal cancer drugs make cancer cells more aggressive
Scientists from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) and the Mannheim University Medical Center conducted research and discovered that some cancer drugs (MEK Inhibitors) activates the cancer-promoting Wnt signaling pathway in colorectal cancer cells.
This activity determines that these colorectal cancer drugs are ineffective. Even worse, they can enrich the stem-cell like tumor cells that are resistant to many therapies. That is why after an apparent remission, the cancer will come back with high resistance to therapies and eventually kill the patients.
Cells respond to environmental stress through the biochemical reactions of the Wnt signaling pathway, which was initially believed to be involved in the development of cancer and now known to play a role in many pathological processes and cancer.
“Wnt signals affect the balance between cells with stem cell characteristics and differentiated cells both in the healthy intestine and in colon cancer,” says Michael Boutros from the German Cancer Research Center (DKFZ) and the Mannheim Medical Faculty of the University of Heidelberg.